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- W3031194948 abstract "ObjectiveBrainstem clinically isolated syndrome (BCIS) may herald multiple sclerosis (MS) or neuromyelitis (NMO), or it may occur as an isolated syndrome. However, the role of anti- aquaporin 4 antibodies in the conversion of BCIS to NMO remains uncertain.MethodsThirty-one BCIS patients hospitalized in our hospital from July 2006 to December 2010 were chosen in our study; their clinical data were retrospectively analyzed; according to the presence of anti-AQP4 antibodies, they divided into two groups: anti-AQP4(+)BCIS group (n=14) and anti-AQP4(-)BCIS group (n=17). The differences of clinical manifestations, imaging features and cerebrospinal fluid level between the two groups were compared and the conversion of patients from the two groups was analyzed.ResultsNine (64.29%) anti-AQP4(+)BCIS patients converted to NMO, while only two (11.76%) anti-AQP4(-)BCIS patients progressed to NMO, over a mean follow-up period of 36.10±18.94 months; significant difference of conversion rate was noted between the two groups (P<0.05). Anti-AQP4(+)BCIS patients demonstrated a higher immunogamm globulin (IgG) index (0.68±0.43 vs. 0.47±0.19, P=0.018) and Kurtzke Expanded Disability Status Scale (EDSS) scores at the last visit of follow-up (4.64±0.92 vs. 2.71±0.81, P=0.000) than anti-AQP4(-)BCIS patients. Gastroenterology-related brainstem symptoms occurred more frequently in anti-AQP4(+)BCIS patients than that in anti-AQP4(-)BCIS patients (71.43% vs. 23.53%, P=0.001). In brainstem MR imaging, the anti-AQP4(+)BCIS patients were observed having medulla-predominant involvement in the sagittal view (78.57%) and dorsal-predominant involvement in the axial view (78.57%), which were significantly different as compared with those in the anti-AQP4(-)BCIS patients (35.29% and 41.17%, P<0.05).Conclusionanti-AQP4(+)BCIS may represent an early, isolated syndrome of NMO spectrum disorder.Key words: Brainstem clinically isolated syndrome; Aquaporin 4; Neuromyelitis optica spectrum disorder; Clinical conversion" @default.
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- W3031194948 date "2016-05-15" @default.
- W3031194948 modified "2023-09-25" @default.
- W3031194948 title "Value of anti- aquaporin 4 antibody in conversion of brainstem clinically isolated syndrome" @default.
- W3031194948 doi "https://doi.org/10.3760/cma.j.issn.1671-8925.2016.05.008" @default.
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