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- W3031194961 abstract "ObjectiveTo investigate the relationship between single nucleotide polymorphisms of interleukin 23 receptor (IL-23R) gene and Keshan disease (KD) in Northwest Chinese Han population.MethodsA total of 285 Chinese Han subjects from Huangling, Shaanxi, including 79 KD patients (case group) and 206 control subjects (control group) were involved in this study. Genomic DNA was extracted from peripheral venous blood. The polymorphism of genetic variation was genotyped by matrix-assisted laser desorption/ionization-time of flight (MALDI-TOF). All sample groups were tested for Hardy-Weinberg equilibrium using goodness-of-fit χ2 test. Differences in genotype distribution between two groups were compared by χ2 test. Logistic regression analysis was applied to detect association using age as a confounding factor.ResultsThe gene frequency distribution of IL-23R gene rs10889677 in case group and control group conformed to the Hardy-Weinberg equilibrium (χ2=0.254, P > 0.05). Correlation analysis results: the difference of genotype frequency of IL-23R gene rs10889677 in case group (CC, CA, AA were 6.3%, 36.7%, 57.0%, respectively) and control group (CC, CA, AA were 5.3%, 43.2%, 51.5%, respectively) was not statistically significant (χ2=1.008, P > 0.05). After age adjustment, there was no significant difference in genotype frequency of IL-23R gene rs10889677(χ2adj=0.669,P>0.05)between two groups.ConclusionThere is no correlation between IL-23R gene rs10889677 and KD in Northwest Chinese Han population.Key words: Polymorphism, single nucleotide; Receptors, interleukin-23; Keshan disease" @default.
- W3031194961 created "2020-06-05" @default.
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- W3031194961 date "2019-05-20" @default.
- W3031194961 modified "2023-09-27" @default.
- W3031194961 title "An association between single nucleotide polymorphisms of IL-23R gene and Keshan disease in Northwest Chinese Han population" @default.
- W3031194961 doi "https://doi.org/10.3760/cma.j.issn.2095-4255.2019.05.004" @default.
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