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• W3031201531 abstract "Abstract Constitutive heterochromatin at the pericentric regions of chromosomes undergoes dynamic changes in its epigenetic and spatial organization during spermatogenesis. Accurate control of pericentric heterochromatin is required for meiotic cell divisions and production of fertile and epigenetically intact spermatozoa. In this study, we demonstrate that pericentric heterochromatin is expressed during mouse spermatogenesis to produce major satellite repeat (MSR) transcripts. We show that the endonuclease DICER localizes to the pericentric heterochromatin in the testis. Furthermore, DICER forms complexes with MSR transcripts, and their processing into small RNAs is compromised in Dicer1 knockout mice leading to an elevated level of MSR transcripts in meiotic cells. We also show that defective MSR forward transcript processing in Dicer1 cKO germ cells is accompanied with reduced recruitment of SUV39H2 and H3K9me3 to the pericentric heterochromatin and meiotic chromosome missegregation. Altogether, our results indicate that the physiological role of DICER in maintenance of male fertility extends to the regulation of pericentric heterochromatin through direct targeting of MSR transcripts." @default.
• W3031201531 created "2020-06-05" @default.
• W3031201531 creator A5008442979 @default.
• W3031201531 creator A5050194796 @default.
• W3031201531 creator A5064331844 @default.
• W3031201531 creator A5081925895 @default.
• W3031201531 creator A5089939765 @default.
• W3031201531 date "2020-06-02" @default.
• W3031201531 modified "2023-10-15" @default.
• W3031201531 title "DICER regulates the expression of major satellite repeat transcripts and meiotic chromosome segregation during spermatogenesis" @default.
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• W3031201531 doi "https://doi.org/10.1093/nar/gkaa460" @default.
• W3031201531 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7367195" @default.
• W3031201531 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32484548" @default.
• W3031201531 hasPublicationYear "2020" @default.
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