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- W3031210904 abstract "ObjectiveTo investigate the correlation of blood-brain barrier (BBB) damage and depression in patients with cerebral small vessel disease (CSVD).MethodsConsecutive patients with CSVD admitted to hospital were enrolled prospectively. The patients completed head MRI and cerebrospinal fluid (CSF) examination after admission. The BBB damage degree was evaluated by using albumin CSF/serum ratio (Q-Alb). At 3 months after onset, the depression was assessed according to the Hamilton depression scale (HAMD) and the American Diagnostic and Statistical Manual of mental disorders, 4th edition (DSM-Ⅳ). The correlation between the BBB damage and depression in patients with CSVD was analyzed.ResultsA total of 130 consecutive patients with CSVD were enrolled, including 58 (44.62%) had depression within 3 months. There were significant differences in the proportions of patients with lacunar infarction (43.10% vs.26.39%; χ2=4.008, P=0.045), leukoaraiosis (75.86% vs. 58.33%; χ2=4.408, P=0.036), and cerebral microbleed (27.59% vs. 12.50%; χ2=4.707, P=0.030), and baseline National Institutes of Health Stroke Scale (NIHSS) scores (5.02±2.51 vs. 3.60±2.43; t=3.256, P=0.001), Fazekas scales of deep white matter (2.35±1.00 vs. 1.56±1.05; t=4.358, P<0.001) and the proportion of Q-Alb category (χ2=6.852, P=0.033) between the depression group and the non-depression group. Multivariate logistic regression analysis showed that the baseline NIHSS scores (odds ratio [OR] 1.248, 95% confidence interval [CI] 1.027-1.517; P=0.026), leukoaraiosis (OR 14.786, 95% CI 1.776-123.111; P=0.013), Fazekas scales of deep white matter (OR 1.847, 95% CI 1.210-2.819; P=0.004), and Q-Alb (OR 30.417, 95% CI 3.662-252.643; P=0.004) had significant independent correlation with depression.ConclusionsThe BBB damage is independently associated with depression in patients with CSVD.Key words: Cerebral Small Vessel Diseases; Depression; Blood-Brain Barrier; Albumins; Stroke; Brain Ischemia; Risk Factors" @default.
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- W3031210904 date "2016-04-28" @default.
- W3031210904 modified "2023-10-14" @default.
- W3031210904 title "Correlation between blood-brain barrier damage and depression in patients with cerebral small vessel disease" @default.
- W3031210904 doi "https://doi.org/10.3760/cma.j.issn.1673-4165.2016.04.005" @default.
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