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- W3031215836 abstract "ObjectiveTo investigate the inhibitory effect of Tubacin, a selective inhibition of histone deacetylase 6 (HDAC6), on the release of inflammatory mediators in lipopolysaccharide (LPS) activated microglias and its underlying mechanism.MethodsBV-2 microglias were divided into control group (conventional culture), LPS group (100 ng/mL LPS), Tubacin treatment group (1 μmol/L Tubacin) and experimental group (LPS 100 ng/mL+Tubacin 1 μmol/L). The levels of interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) were detected by enzyme linked immunosorbent assay (ELISA). The production of nitric oxide (NO) was assayed by Griess reagent and the expression of inducible nitric oxide synthase (iNOS) was measured by Western blotting. The oxidative stress levels of BV-2 cells were determined by reactive oxygen species (ROS) and superoxide dismutase (SOD) assays.ResultsAs compared with those in the control group, the productions of IL-6, TNF-α and NO were notably increased, the iNOS protein expression was significantly up-regulated, the ROS level was apparently elevated and the SOD activity was significantly decreased in the LPS group (P<0.05). As compared with those in the LPS group, the productions of IL-6, TNF-α and NO were notably decreased, the iNOS protein expression was significantly down-regulated, the ROS level was apparently lessened and the SOD activity was significantly increased in the experiment group (P<0.05).ConclusionTubacin curbs the release of inflammatory mediators in activated microglial cells induced by LPS, whose effect may be achieved through decreasing oxidative stress levels in LPS activated microglial cells.Key words: Microglia; Tubacin; Histone deacetylase 6; Inflammatory mediator; Oxidative stress" @default.
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- W3031215836 date "2017-04-15" @default.
- W3031215836 modified "2023-09-26" @default.
- W3031215836 title "Experimental study on Tubacin inhibiting release of inflammatory mediators in lipopolysaccharide activated microglial cells" @default.
- W3031215836 doi "https://doi.org/10.3760/cma.j.issn.1671-8925.2017.04.008" @default.
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