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- W3031227599 abstract "A host factor named Sterile Alpha Motif domain and HD domain containing protein 1 (SAMHD1) has been recently confirmed to be one of HIV-1 inhibitory factors.This molecule can restrict the replication of HIV-1 in myeloid cells and resting CI4 +T cells by hydrolysising intracellular deoxy-ribonucleoside triphosphate (dNTPs).Viral protein x(Vpx) produced by HIV-2 recruites human SAMHD1 onto ubiquitin ligase complex.Then proteasome degrades SAMHD1.There is an evolutionary arms race between SAMHD1 in primate and Vpx encoded by lentivirus.According to latest research findings,the struction and mechanism of SAMHD1,and the interaction and evolution of SAMHD1 and Vpx are summarized in this article.Key words: HIV-1; SAMHD1; Vpx" @default.
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- W3031227599 date "2013-04-25" @default.
- W3031227599 modified "2023-09-22" @default.
- W3031227599 title "SAMHD1:a new HIV-1 inhibitory factor" @default.
- W3031227599 doi "https://doi.org/10.3760/cma.j.issn.1673-4149.2013.02.013" @default.
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