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- W3031227962 abstract "Objective To investigate the value of urinary cellular fibronectin (cFN) in diagnosis,prognosis and postoperative surveillance of bladder cancer.Methods Urinary cFN were determined in 52patients preoperatively (preoperative group),and in 27 patients without residual tumour (no residual group),8 patients with residual tumour (residual group) postoperatively,as well as 17 healthy volunteers (control group) from Aug 2010 to Feb 2011 by Enzym-Linked immunosorbent Assay (ELISA) test.The differences in cFN levels among groups were analyzd.Based on T stage,grade and tumor size,52 patients in the preoperative group were divided into nonmuscle-invasive group (T1 stage) and muscle-invasive group (T2-T4 stage),low-grade group (G1-G2) and high-grade group (G3),and small tumor group (diameter＜3 cm) and large tumor group (diameter≥ 3 cm),respectively.Relationship between preoperative urinary cFN levels and tumor clinicopathologic factors was analyzed.A receiver operating characteristic (ROC)curve was plotted to determine the ability of urinary cFN to distinguish patients with and without residual tumor.Results The levels of urinary cFN in both preoparative group (1809.78± 1657.39 μg/L) and residual group (1311.67±500.09 μg/L) were significantly higher than those of no residual group (878.71±355.68 μμg/L) and those of control group (898.50±318.98 μg/L),respectively (P＜0.05).No significant difference was observed between residual group and preoperative group (P＞0.05).Preoperative urinary cFN levels were associated with tumor clinicopathologic factors and significantly higher values were observed in muscle-invasive group (2188.67±2048.93 vs 1485.02± 1150.69 μg/L,P＜0.05) and large tumor group (3643.5942673.89 vs 1373.16±876.88 μg/L,P＜0.05).There was also a significant correlation of urinary cFN levels with tumor size (r=0.471,P＜0.05).The ROC curve showed a sensitivity of 75％ and a specificity of 67％ in detecting residual tumour.Conclusions Urinary cFN as a subtype of FN,in addition to being one of the best markers in diagnosis and prognosis of bladder cancer,is valuable in determining the presence of residual tumour after surgery.Key words: Cellular fibronectin; Bladder cancer; Diagnosis; Postoperative surveillance" @default.
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- W3031227962 date "2013-12-15" @default.
- W3031227962 modified "2023-09-23" @default.
- W3031227962 title "Urinary cellular fibronectin in diagnosis and postoperative surveillance of bladder cancer" @default.
- W3031227962 doi "https://doi.org/10.3760/cma.j.issn.1000-6702.2013.12.012" @default.
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