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• W3031228812 abstract "ObjectiveTo investigate the relations between the expression of nuclear factor kappa B of B cells in the peripheral blood(PB) and the apoptosis with B cell in patients with rheumatoid arthritis (RA).MethodsB cells in the PB of 48 RA and 30 healthy individuals were isolated by MACS and Western blot was used to detect the expression of NF-κBp50, NF-κBp65, IκBα, phosphor-NF-κBp65 (P-NF-κBp65), phosphor- IκBα(P-IκBα), apoptosis related proteins Caspase-3 and Bcl-2.The levels of interleukin(IL)-17, IL-6, tumor necrosis factor-α(TNF-α)in patients with RA were measured by enzyme-linked immunosorbent assay(ELISA). The proportions of apoptosis of B cells in the PB of patients with RA and healthy controls were determined by flow cytometry.T-test and Pearson correlation analysis were used to analyze the data.ResultsThe expression of P-NF-κBp65 and P-IκBα of B cells in the PB of patients with RA was significantly higher than that of control group[(30.5±10.1)vs.(13.4±4.8); (25.6±9.2)vs.(16.5±5.8)], the difference was statistically significant(t=5.071, t=4.643, both P 0.05). The expression of P-NF-κBp65 and Bcl-2 were positively correlated in patients with RA (r=0.311, P<0.05). There was a negative correlation between the level of P-NF-κBp65 and the rate of apoptosis of B cells in the patients with RA(r=-0.472, P<0.05). The expression of P-IκBα has no correlation with the rate of apoptosis of B cells in the patients with RA (r=-0.075, P=0.104).ConclusionThe expression of P-NF-κBp65 and P-IκBα dramatically increased in B cell of PB from RA patients and the expression of P-NF-κBp65 is closely related Bcl2 and the rate of B cell apoptosis, indicating that the activation of NF-κB signal pathway could regulate Bcl-2 expression which inhibit B cell apoptosis in the patients with RA.Key words: Rheumatoid arthritis; B cell; Nuclear factor kappa B; Bcl-2; Cell apoptosis" @default.
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• W3031228812 date "2018-03-05" @default.
• W3031228812 modified "2023-09-23" @default.
• W3031228812 title "Associations of expression of nuclear factor kappa B and apoptosis with B cell in patients with rheumatoid arthritis" @default.
• W3031228812 doi "https://doi.org/10.3760/cma.j.issn.1673-4394.2018.02.014" @default.
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