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- W3031242145 abstract "目的 观察地塞米松(DXM)对视网膜蓝光损伤的保护作用及对c-Fos蛋白表达的影响.方法 将44只Lewis大鼠分为正常对照组4只,DXM治疗组和生理盐水(NS)组各20只,分别于腹腔内注射DXM(35 mg/kg)及NS(5 mL/kg).持续蓝光(3 012±115)Lux照射1 h后暗适应0、6、12、24、48 h,摘除眼球行形态学、免疫组织化学及TUNEL检测.结果 NS组光照后0 h视网膜外核层(ONL)中凋亡细胞及c-Fos蛋白的表达立即上调,24 h达峰值,48 h明显下降.DXM治疗组的变化规律基本同上,但光照后6、12、24 h视网膜ONL中凋亡细胞数目明显下降;c-Fos的表达水平明显降低.结论 DXM对蓝光诱导的大鼠视网膜光损伤具有保护作用,该作用可能与c-Fos蛋白表达的降低有关。" @default.
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- W3031242145 date "2008-01-15" @default.
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- W3031242145 title "The effect of dexamethasone on retinal injury induced by blue light in rats" @default.
- W3031242145 doi "https://doi.org/10.3760/cma.j.issn.2095-0160.2008.01.011" @default.
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