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• W3031248572 abstract "ObjectiveTo observe the clinical efficacy and security of high-dose prostaglandin E1 pulse therapy in the diabetic foot patients with peripheral vascular disease.MethodsBased on the same treatment including dressing change, anti-inflammatory and glycemic control, 151 patients with diabetic foot (Wagner grade 1-3) treated from January 2009 to July 2014 in the Sixth People's Hospital in Shanghai were divided into two groups: treatment group (n=85, treated with high-dose prostaglandin E1 (40 μ g/d) for 1 week), and the control group (n=66, treated with conventional dose of prostaglandin E1 (10 μ g/d) for 2 weeks). Then the healing rate, healing time, amputation rate, ankle-brachial index (ABI), numbness, pain and coldness visual analogue scale (VAS) score and adverse reactions were recorded and analyzed after 3 months of therapy. The t test or Chi-square test was used when data were compared between groups.ResultsThe healing rate in Wagner grade 2 and 3 patients in treatment group increased significantly when compared with that in relevant control group (76.0% vs 61.1% and 69.6% vs 42.1%, χ2=5.21, 15.90, both P<0.05). And the healing time in Wagner grade 2 patients in treatment group was obviously shorter than that in the counterparts in control group ((10.9±4.3) weeks vs (7.7±3.4) weeks,t=2.225,P<0.05). After 3 months of treatment, the ABI increased in the two groups, but only significant difference in ABI was found in Wagner grade 2 patients in treatment group before and after the therapy (0.60±0.21 vs 0.75±0.22,t=2.432,P<0.05). The VAS scores in Wagner grade 1-3 patients in treatment group were all significantly lower than those before the therapy (t=2.292, 2.553, 2.985, all P<0.05), and VAS scores decreased significantly only in Wagner grade 2 and 3 patient in control group (t=2.120, 2.086, both P<0.05). Meanwhile there was no significant differences in the adverse reactions rates between the two groups during the observation period.ConclusionHigh-dose prostaglandin E1 pulse therapy can improve the wound healing rate in Wagner grade 2 and 3, shorten the healing time in Wagner grade 2, relieve lower limbs pain with safety for diabetic foot patients.Key words: Diabetic foot; Prostaglandin E1; Peripheral vascular disease; Wound healing" @default.
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• W3031248572 date "2015-07-27" @default.
• W3031248572 modified "2023-09-30" @default.
• W3031248572 title "High-dose prostaglandin E1 pulse therapy improves the healing rate of foot ulcer complicated with peripheral vascular disease in diabetic patients" @default.
• W3031248572 doi "https://doi.org/10.3760/cma.j.issn.1674-5809.2015.07.004" @default.
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