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- W3031266888 abstract "ObjectiveTo study and analyze the correlation between cognitive dysfunction and ischemic leukodystrophy in elderly patients.MethodsEighty-eight elderly patients with ischemic leukodystrophy hospitalized in Pingmei Shenma Medical Group General Hospital from March 2016 to October 2017 were selected as research group. In addition, 30 healthy elderly patients who underwent physical examination in the same hospital were selscted as control group. The scores of the Montreal cognitive assessment (MoCA) of the two groups were analyzed and compared, and the relationship between the severity of disease and scores of MoCA scale was analyzed. Patients in research group were divided into cognitive dysfunction group (54 cases) and non-cognitive dysfunction group (34 cases), according to cognitive dysfunction development, for comparison on the basic data by multivariate Logistic regression analysis.ResultsThe total score, visual space and executive function, attention, calculation, language, delayed recall and directional score of research group were lower than those of control group, and the differences were statistically significant (all P<0.05). The total score, delayed recall, directional score all showed a trend of gradually reduction in mild group, moderate group and medium group, contrast differences between groups were statistically significant (all P<0.05). The age, proportion of hypertension and diabetes in cognitive dysfunction group was higher than those in non-cognitive impairment group, and the difference was statistically significant (all P<0.05). Multivariate logistic regression analysis revealed that age, hypertension and diabetes were the independent risk factors of cognitive dysfunction in elderly patients with ischemic leukodystrophy (all P<0.05).ConclusionsCognitive dysfunction in the elderly is closely related to ischemic leukodystrophy, and with the increase of the severity of ischemic leukodystrophy, the more obvious the cognitive dysfunction is.Key words: Ischemic leukodystrophy; Cognitive dysfunction; Elderly; Correlation analysis" @default.
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- W3031266888 date "2018-11-10" @default.
- W3031266888 modified "2023-09-24" @default.
- W3031266888 title "Correlation analysis of cognitive dysfunction and ischemic leukodystrophy in elderly patients" @default.
- W3031266888 doi "https://doi.org/10.3760/cma.j.issn.1674-4756.2018.21.014" @default.
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