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- W3031278082 abstract "Objective To study the effect of simvastatin on the levels of plasma nitric oxide (NO), calcitonin gene-related peptide (CGRP) and endothelin (ET) in patients with coronary heart disease (CHD) complicated with congestive heart failure (CHF). Methods Sixty-eight cases of CHD complicated with CHF were randomly divided into two groups, i.e. the routine medication group consisting of 34 cases treated with digoxin, Hydro-Saluril and isosorbide dinitrate, and the routine medication plus simvastatin group consisting of the same number of cases. In addition, there was another group of 34 healthy people without any treatment. Greiss was used to measure the level of NO, and radioimmunoassay (RIA) was used to measure the levels of plasma CGRP and ET before and after treatment. Results The levels of NO and CGRP in patients with CHD complicated with CHF were obviously lower than those of the normal group before treatment (P<0.01), and the level of ET was also markedly higher than that of the normal group (P<0.01). Significant improvement could be seen in CGRP and ET in both groups, with more significant improvement in the routine medication plus simvastatin group (P<0.05). Conclusions Routine medication and simvastatin could obviously improve metabolic imbalance of NO, CGRP and ET in patients with CHD complicated with CHF.Key words: Simvastatin; Coronary heart disease; Congestive heart failure; Calcitonin gene-related peptide; Endothelin" @default.
- W3031278082 created "2020-06-05" @default.
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- W3031278082 date "2009-04-28" @default.
- W3031278082 modified "2023-09-28" @default.
- W3031278082 title "Effect of simvastatin on vascular endothelial function in patients with coronary heart disease complicated with heart failure" @default.
- W3031278082 doi "https://doi.org/10.3760/cma.j.issn.1009-6906.2009.02.027" @default.
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