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- W3031281017 abstract "Objective To explore the application value of angiotensinⅡ （ATⅡ）, neuropeptide Y（NPY）, insulin-like growth factor 1（IGF-1） and high sensitive C-reaction protein（hs-CRP） levels in e-valuation of the severity of coronary heart disease （CHD）. Methods The plasma ATⅡ, NPY, IGF-1 and hs-CRP levels in 157 patients with CHD [ including 51 cases with stable angina （ SA ） , 45 cases with unstable angina （USA） and 61 cases with acute myocardial infraction （AMI）] were measured by radioim-munoassay, enzyme immunoassay and high sensitive enzyme immunoassay and were compared with 60 health controls. Results The plasma ATⅡlevel in 157 patients with CHD was significantly higher than those in 60 controls（tSA ATⅡ=2.257, P〈0.05; tUSAATⅡ=3.018, P〈0.01; tAMIATⅡ=4.143, P〈0.001）. The plasma NPY level in 157 patients with CHD was higher than those in 60 controls （tSANPY=1.413, P>0.05;tUSANPY=2.148, P〈0.05; tAMINPY=3.068, P〈0.01）, but there were no significant difference between SA pa-tients and the 60 conrols. The plasma IGF-1 level in 157 patients with CHD was significantly higher than those in 60 controls （tSA IGF-1=2.121, P〈0.05; tUSA IGF-1=2.937, P〈0.01; tAMI IGF-1=4.217, P〈0.001）. The plasma hs-CRP level in 157 patients with CHD was significantly higher than those in 60 controls （tSA hs-CRP=2.095, P〈0.05; tUSA hs-CRP=2.867, P〈0.01; tAMI hs-CRP=4.349, P〈0.001）. The four plasma biomarkers were increased with severity of CHD. Conclusion The plasma ATⅡ, NPY, IGF-1 and hs-CRP levels were＆amp;nbsp;valuable indexes for judging the severity of patients with CHD, and could be used for follow-up.Key words: Coronary heart disease; Angiotensin II ; Neuropepti-de Y; Insulin-like growth factor I ; High sensitive C-reaction protein; Radioimmunoassay; Immunoenzyme techniques" @default.
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- W3031281017 date "2014-05-25" @default.
- W3031281017 modified "2023-09-25" @default.
- W3031281017 title "The application value of plsama ATII, NPY, IGF-1 and hs-CRP levels in evaluation of coronary heart disease severity" @default.
- W3031281017 doi "https://doi.org/10.3760/cma.j.issn.1673-4114.2014.03.007" @default.
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