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- W3031284629 abstract "Objective To investigate the mRNA and protein expression of coiled-coil domain containing 67 (CCDC67) gene in papillary thyroid carcinoma (PTC).Methods Reverse transcription-polymerase reaction (RT-PCR) and Western blotting were used to detect the CCDC67 mRNA and protein levels in the cell lines of thyroid carcinoma and 56 human PTC specimens and their matched adjacent non-cancerous epithelium (NCE).Results There is no expression of CCDC67 in thyroid carcinoma cell lines.All cases had expression of CCDC67 mRNA and protein in adjacent normal tissues,but the expression of CCDC67 mRNA was down-regulated significantly,only 41.4％ (23/56) in 56 cases of thyroid carcinoma appeared CCDC67 mRNA expression,it was correlated with the tumor TNM stage,pathological grade and lymph node metastasis (x2 =11.368,4.861,6.321,P ＜ 0.05).The expression of CCDC67 protein was down-regulated significantly,only 46.4％ (26/56) in 56 cases of thyroid carcinoma appeared CCDC67 protein expression,it was correlated with the tumor TNM stage,pathological grade and lymph node metastasis (x2 =4.229,4.314,5.540,P ＜ 0.05).Furthermore there was a distinct correlation between the mRNA and protein expression of CCDC67 gene (x2 =25.775,P ＜ 0.01).Conclusion There is no expression of CCDC67 in thyroid carcinoma cell lines.The expression of CCDC67 mRNA and protein was down-regulated in PTC.A lower expression of CCDC67 gene may play an important role in the carcinogenesis and progression of PTC.Key words: Papillary thyroid carcinoma; Coiled-coil domain containing 67; Reverse transcription-polymerase reaction; Western blotting" @default.
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- W3031284629 date "2014-11-08" @default.
- W3031284629 modified "2023-09-23" @default.
- W3031284629 title "Correlation of mRNA and protein expression of coiled-coil domain containing 67 gene in papillary thyroid carcinoma" @default.
- W3031284629 doi "https://doi.org/10.3760/cma.j.issn.1001-9030.2014.11.059" @default.
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