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- W3031286146 abstract "Objective To detect the express of X-box binding protein 1 (XBP1),vascular endothelial growth factor C (VEGF-C),mRNA in the tissue of hepatoma; demonstrating that it exist activation of unfold protein response (UPR) in process of growth,and the expression of UPR was higher than normal tissue;approaching the mechanism of action in the growth of hepatoma,searching the new target for the therapy of hepatoma.Methods To study the mRNA of XBP1,VEGF-C in 42 case example of hepatome,15 case paired adjacent hepatic tissues to carcinoma and 15 case normal hepatic tissues by reverse transcription-polymerase chain reaction (RT-PCR).To qualitation check the expression of XBP1 and VEGF-C in the level of protein in 57 case example of hepatome and normal hepatic tissues,by Western blotting.Results The express of XBP1 mRNA in hepatoma tissue,adjacent hepatic tissue to carcinoma and normal hepatic tissue respectively was0.4396 ± 0.0241,0.4152 ±0.0252,0.4095 ± 0.0149; The express of XBP1 mRNA was higher in hepatoma than others ( P ＜ 0.05 ).The express of VEGF-C mRNA in hepatoma tissue,adjacent hepatic tissue to carcinoma and normal hepatic tissue respectively was 0.4447 ± 0.0335,0.4195 ± 0.0334,0.4019 ±0.0259.The express of VEGF-C mRNA was higher in hepatoma than others ( P ＜0.05).The experiment indicate:the two protein all express in the hepatoma tissue and normal hepatic tissue,but they were higher in hepatoma tissue than in the normal hepatic tissue.Conclusion It exist activation of UPR in process of growth.The express of XBP1,VEGF-C protern and their mRNA was accordant,all of them were higher in hepatoma tissue than in normal hepatic tissue.The changes of these gene and protern is possible to have the relationship with the carcinogenesis,growth and transfer of hepatoma.And it may have significant effect in molecule mechanism of hepatoma.It also descripte that unfold protein response may have very important role in the pocess of carcinogenesis.Key words: Hepatoma; X-box binding protein 1; Vascular endothelial growth factor C; Reverse transcription-polymerase chain reaction; Western blot" @default.
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- W3031286146 date "2012-05-08" @default.
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- W3031286146 title "The expression and significance of the correlation factor of unfolded protein response: immunoglobulin-binding protein, vascular endothelial growth factor-C in hepatoma" @default.
- W3031286146 doi "https://doi.org/10.3760/cma.j.issn.1001-9030.2012.05.027" @default.
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