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- W3031287304 abstract "Interleukin 33 (IL-33) is a member of the IL-1 cytokine family, which is a key cytokine involved in Th2-type inflammatory responses and allergic airway diseases.Abundantly expressed in lung epithelial cells, IL-33 plays critical roles in both innate and adaptive immune responses in mucosal organs.IL-33 promotes allergen specific Th2 immune response and activates various cell types involved in asthma pathogenesis (mast cells, basophils, eosinophils, etc). Increasing evidence indicates that IL-33 plays an important role in the pathogenesis of asthma, mainly by inducing Th2 immune responses.In this article, we reviewed IL-33 from its molecular structure, bioactivities and its role in the pathogenesis of asthma.Key words: Interleukin-33; Asthma, bronchial; Helper T cell" @default.
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- W3031287304 date "2019-06-20" @default.
- W3031287304 modified "2023-09-23" @default.
- W3031287304 title "Research advances on IL-33 and bronchial asthma" @default.
- W3031287304 doi "https://doi.org/10.3760/cma.j.issn.1673-436x.2019.12.009" @default.
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