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- W3031287437 abstract "Objective To investigate the protective effect of astragaloside Ⅳ pretreatment against liver ischemia/reperfusion (I/R) injury in mice. Methods Sixty male C57BL/6 mice were randomized into four groups (15 mice in each group):group A:sham surgery with saline injection,group B:sham surgery with astragaloside Ⅳ injection,group C:I/R group with saline injection,group D:I/R and astragaloside Ⅳ injection.Mice were pretreated by daily intraperitoneal injection of saline or astragaloside Ⅳ (24 mg · kg-1 · d-1 ) for one week.The mouse partial liver model of I/R injury was established,and samples were collected at the 24 h after the I/R injury.Serum ALT and AST levels were determined,the histologic changes were observed by HE ALT:C:(4146 ±500) U/L vs.D:(2318 ±289) U/L t =7.08 P ＜0.05].In comparison with group 3,astragaloside Ⅳ reduced NF-κB nuclear expression.ELISA showed astragaloside Ⅳ significantly inhibit the levels of IL-1 β,IL-6,and TNF-α in the serum (IL-1β:t =10.04;IL-6:t =6.281;TNF-α:t =6.817; P ＜0.05).Conclusions Pretreatment with astragaloside Ⅳ effectively protect against liver ischemia/reperfusion injury in mice.Key words: Astragalus membranaceus; Reperfusion injury; NF-kappa B" @default.
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- W3031287437 date "2012-09-25" @default.
- W3031287437 modified "2023-09-24" @default.
- W3031287437 title "Protection of astragaloside IV pretreatment against liver ischemia/reperfusion injury in mice" @default.
- W3031287437 doi "https://doi.org/10.3760/cma.j.issn.1007-631x.2012.09.017" @default.
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