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- W3031295612 abstract "目的 分析黑龙江省Ⅰ型人免疫缺陷病毒 (human immunodeficiency virus type 1, HIV-1)原代分离株包膜糖蛋白的变异性及表型特征.方法从一名HIV阳性但未发病的感染者外周血单个核细胞提取DNA,采用保守引物进行HIV包膜直接克隆,进行序列分析及系统树分析.构建了一株带该包膜蛋白的伪病毒并利用表达CXCR4和CCR5的靶细胞进行了感染实验,观察该病毒包膜利用辅助受体的表型特征.结果共获得2个有功能全长env克隆,分别命名为CHNHLJ03009c34 (GenBank 序列号为AY905493)和CHNHLJ03009c33.用全长env氨基酸序列与国内外分离株进行同源性比较分析发现,与分离株CHNHLJ03009c34的包膜同源性最高的病毒为云南的HIV-1 B'亚型分离株RL42,同源性为91.52%.系统发育分析结果表明,该株为泰国B'亚型,与云南分离株RL42的遗传距离最近.对包膜蛋白结构分析结果显示,分离株CHNHLJ03009c34包膜在抗原性和亲水性上与RL42没有明显差别.感染性检测结果显示该病毒只能感染U87.CD4.CCR5细胞, 不能感染U87.CD4.CXCR4细胞.结论本研究从黑龙江省一名HIV-1阳性者克隆到HIV-1 CHNHLJ03009病毒的包膜基因,该病毒属于B'亚型(泰国亚型),为R5亲嗜性毒株.该包膜基因克隆为首次报道的黑龙江分离株。" @default.
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- W3031295612 date "2005-11-30" @default.
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- W3031295612 title "Cloning and analysis of HIV-1 envelope isolated from an infected individual in Heilongjiang province" @default.
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