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• W3031304459 abstract "Objective To evaluate the role of glucocorticoid receptor (GR) in acute lung injury (ALI) induced by lipopolysaccharide (LPS) in rats.Methods Sixty male Sprague-Dawley rats,weighing 180-230 g,were randomly divided into 4 groups:control group (group C,n =6) ; GR specific inhibitor RU486 group (group R,n =6) ; ALI group (n =24) ; RU486 + ALI group (group RA,n =24).ALI was induced by injection of LPS 5 mg/kg via the tail vein in groups ALI and RA,while the equal volume of normal saline was given in group C and RU486 20 mg/kg was injected subcutaneously in group R.RU486 20 mg/kg was injected subcutaneously 90 min before LPS administration in group RA.Eight rats were chosen at 1,3,and 6 h after LPS administration (T11-3) in groups ALI and RA and at 1 h after normal saline or RU486 administration in groups C and R and sacrificed.The lungs were removed for determination of the expression of phosphorylated p38 mitogen-activated protein kinase (pp38MAPK) and mitogen-activated protein kinase phosphatase-1 (MKP-1) in lung tissues.The concentrations of albumin and TNF-α in bronchoalveolar lavage fluids (BALF) were detected,histopathological changes in lung tissues were observed and apoptosis index (AI) was calculated at T3.Another 32 Sprague-Dawley rats,weighing 180-230 g,were randomly divided into 2 groups (n =16 each):group ALI1 and group RA1.The rats were treated as the method mentioned above and observed for the 48 h survival rate.Results Compared with group C,the concentrations of protein and TNF-α in BALF and AI were significantly increased,the histopathological damage was aggravated,and p-p38MAKP expression was up-regulated at T1-3 in groups ALI and RA,and MKP-1 expression was downregulated at T2,3 in group ALI and at Ti-3 in group RA (P ＜ 0.05).Compared with group ALI,the concentrations of protein and TNF-α in BALF and AI were significantly increased,p-p38MAKP expression was up-regulated at T1-3 (P ＜ 0.05),and no significant change was found in MKP-1 expression at T2,3 in group RA (P ＞ 0.05).The 48 h survival rate was significantly lower in group RA1 than in group ALI1 (P ＜ 0.05).Conclusion Glucocorticoid receptors are involved in the development of LPS-induced ALI,and the mechanism may be related to the inhibition of p38MAPK signal transduction pathways and decrease in cell apoptosis in rat lung tissues.Key words: Receptors, glucocorticoid;  Respiratory distress syndrome, adult;  Endotoxins;  p38 mitogen-activated protein kinases;  Lung" @default.
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• W3031304459 date "2013-01-20" @default.
• W3031304459 modified "2023-09-22" @default.
• W3031304459 title "Role of glucocorticoid receptor in acute lung injury induced by lipopolysaccharide in rats" @default.
• W3031304459 doi "https://doi.org/10.3760/cma.j.issn.0254-1416.2013.01.026" @default.
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