Matches in SemOpenAlex for { <https://semopenalex.org/work/W3031304889> ?p ?o ?g. }
- W3031304889 abstract "ABSTRACT Phosphofructokinase, muscle (PFKM), a key glycolytic regulatory enzyme is a potential target for cancer therapeutic studies accredited to the employed inefficient phenomenon known as Warburg effect. PFKM is encoded by PFKM gene located at chromosome 12q13.11. Single nucleotide polymorphisms (SNPs) are known to profoundly affect gene expression and protein function. Therefore, the first attempt was made to computationally identify putative functional PFKM variants. These SNPs were further explored to find their probable association with different cancer types. A total of 9694 SNPs were retrieved from dbSNP database. Of which, only 85 validated SNPs with ≥10% minor allele frequency (MAF) were subjected to analysis by softwares including Ensembl Genome browser, FuncPred (SNPinfo), regulomeDB (v 2.0), SIFT and PolyPhen-2. The relative analysis of output obtained classified the selected-SNPs into 11 highly prioritized (HP), 20 moderately prioritized and 54 not/poorly prioritized SNPs. The 11 HP-SNPs were found to have the highest likelihood of being functionally important, evidenced by previous association of rs2269935, rs11168417, rs11609399 and rs2228500 HP-SNPs with cachexia, lung and breast cancer. The study warrants further experiments to confirm the predictive role of prioritized SNPs in cancer etiology and also provides directions to fellow researchers." @default.
- W3031304889 created "2020-06-05" @default.
- W3031304889 creator A5001688362 @default.
- W3031304889 creator A5003540183 @default.
- W3031304889 creator A5073459160 @default.
- W3031304889 creator A5080172156 @default.
- W3031304889 date "2020-05-29" @default.
- W3031304889 modified "2023-10-16" @default.
- W3031304889 title "In silico analysis of SNPs in human phosphofructokinase, Muscle (PFKM) gene: An apparent therapeutic target of aerobic glycolysis and cancer" @default.
- W3031304889 cites W188868362 @default.
- W3031304889 cites W1940339429 @default.
- W3031304889 cites W1965702066 @default.
- W3031304889 cites W1966118948 @default.
- W3031304889 cites W1968422606 @default.
- W3031304889 cites W1978497228 @default.
- W3031304889 cites W1980112545 @default.
- W3031304889 cites W1981231263 @default.
- W3031304889 cites W1989760304 @default.
- W3031304889 cites W1997470132 @default.
- W3031304889 cites W2003078536 @default.
- W3031304889 cites W2021826885 @default.
- W3031304889 cites W2022101765 @default.
- W3031304889 cites W2030700564 @default.
- W3031304889 cites W2037059484 @default.
- W3031304889 cites W2038367803 @default.
- W3031304889 cites W2042981247 @default.
- W3031304889 cites W2052853583 @default.
- W3031304889 cites W2058084688 @default.
- W3031304889 cites W2072451938 @default.
- W3031304889 cites W2094993935 @default.
- W3031304889 cites W2137886330 @default.
- W3031304889 cites W2141820415 @default.
- W3031304889 cites W2151578735 @default.
- W3031304889 cites W2156073112 @default.
- W3031304889 cites W2156109164 @default.
- W3031304889 cites W2301048285 @default.
- W3031304889 cites W2470337509 @default.
- W3031304889 cites W2533172028 @default.
- W3031304889 cites W2593128963 @default.
- W3031304889 cites W2754515846 @default.
- W3031304889 cites W2786051698 @default.
- W3031304889 cites W2800415104 @default.
- W3031304889 cites W2889646458 @default.
- W3031304889 cites W2895926103 @default.
- W3031304889 cites W2910535306 @default.
- W3031304889 cites W2945494553 @default.
- W3031304889 cites W3014891024 @default.
- W3031304889 doi "https://doi.org/10.1101/2020.05.27.118653" @default.
- W3031304889 hasPublicationYear "2020" @default.
- W3031304889 type Work @default.
- W3031304889 sameAs 3031304889 @default.
- W3031304889 citedByCount "0" @default.
- W3031304889 crossrefType "posted-content" @default.
- W3031304889 hasAuthorship W3031304889A5001688362 @default.
- W3031304889 hasAuthorship W3031304889A5003540183 @default.
- W3031304889 hasAuthorship W3031304889A5073459160 @default.
- W3031304889 hasAuthorship W3031304889A5080172156 @default.
- W3031304889 hasBestOaLocation W30313048891 @default.
- W3031304889 hasConcept C104317684 @default.
- W3031304889 hasConcept C121608353 @default.
- W3031304889 hasConcept C135763542 @default.
- W3031304889 hasConcept C139275648 @default.
- W3031304889 hasConcept C153209595 @default.
- W3031304889 hasConcept C163691529 @default.
- W3031304889 hasConcept C177580304 @default.
- W3031304889 hasConcept C2775905019 @default.
- W3031304889 hasConcept C35794970 @default.
- W3031304889 hasConcept C54355233 @default.
- W3031304889 hasConcept C60644358 @default.
- W3031304889 hasConcept C70721500 @default.
- W3031304889 hasConcept C86803240 @default.
- W3031304889 hasConceptScore W3031304889C104317684 @default.
- W3031304889 hasConceptScore W3031304889C121608353 @default.
- W3031304889 hasConceptScore W3031304889C135763542 @default.
- W3031304889 hasConceptScore W3031304889C139275648 @default.
- W3031304889 hasConceptScore W3031304889C153209595 @default.
- W3031304889 hasConceptScore W3031304889C163691529 @default.
- W3031304889 hasConceptScore W3031304889C177580304 @default.
- W3031304889 hasConceptScore W3031304889C2775905019 @default.
- W3031304889 hasConceptScore W3031304889C35794970 @default.
- W3031304889 hasConceptScore W3031304889C54355233 @default.
- W3031304889 hasConceptScore W3031304889C60644358 @default.
- W3031304889 hasConceptScore W3031304889C70721500 @default.
- W3031304889 hasConceptScore W3031304889C86803240 @default.
- W3031304889 hasLocation W30313048891 @default.
- W3031304889 hasOpenAccess W3031304889 @default.
- W3031304889 hasPrimaryLocation W30313048891 @default.
- W3031304889 hasRelatedWork W1576081620 @default.
- W3031304889 hasRelatedWork W1714044612 @default.
- W3031304889 hasRelatedWork W2013739566 @default.
- W3031304889 hasRelatedWork W2017507057 @default.
- W3031304889 hasRelatedWork W2019337456 @default.
- W3031304889 hasRelatedWork W2093272809 @default.
- W3031304889 hasRelatedWork W2418019426 @default.
- W3031304889 hasRelatedWork W2546327634 @default.
- W3031304889 hasRelatedWork W3193421177 @default.
- W3031304889 hasRelatedWork W4249158346 @default.
- W3031304889 isParatext "false" @default.
- W3031304889 isRetracted "false" @default.
- W3031304889 magId "3031304889" @default.