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- W3031330301 abstract "ObjectiveTo investigate the effect of imipenem cilastatin on pharmacokinetics in elderly patients with pulmonary infection.MethodsEighty-six elderly patients with pulmonary infection were selected, according to the order of filing, all the patients were divided into control group and study group, with 43 cases in each group. Patients in the control group were treated with cefoperazone sodium and sulbactam sodium, and patients in the study group were treated with imipenem cilastatin, the two groups were treated for 1 week. After the course of treatment, the clinical efficacy, bacterial clearance rates, incidences of adverse reaction between the two groups were compared, and the pharmacokinetic changes of imipenem and cilastatin in the study group were analyzed.ResultsThe effective rate of the study group (95.35%)was higher than that of the control group (79.07%) , the difference was significant (P 0.05).ConclusionsImipenem and cilastatin treatment has significant effect on pulmonary infection in the elderly patients, high blood concentration of lung tissue, short half-life, which can effectively improve the treatment effect and the bacterial clearance rate, and has high safety, and has the value of popularization.Key words: Imipenem cilastatin; Pulmonary infection; Pharmacokinetics; Bacterial clearance rate" @default.
- W3031330301 created "2020-06-05" @default.
- W3031330301 creator A5017368316 @default.
- W3031330301 date "2017-09-10" @default.
- W3031330301 modified "2023-09-23" @default.
- W3031330301 title "Effects of imipenem cilastatin on pharmacokinetics in elderly patients with pulmonary infection" @default.
- W3031330301 doi "https://doi.org/10.3760/cma.j.issn.1674-4756.2017.17.010" @default.
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