Matches in SemOpenAlex for { <https://semopenalex.org/work/W3031334606> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W3031334606 endingPage "278" @default.
- W3031334606 startingPage "276" @default.
- W3031334606 abstract "Objective To investigate the effects of Matrine on Akt protein expression in the myocardial tissue in mice with viral myocarditis(VMC) and to approach Matrine's protective mechanism.Methods Four-week-old healthy male Balb/c mice were inoculated intraperitoneally with 0.2ml of 100TCID50 Coxsackie virus B3(CVB3) every day(the.total is for 3 days) to construct VMC animal model. A total of 120 mice were randomly divided into 6 groups:Matrine treatment groups including high does(80 mg/kg), midst does (40 mg/kg) , lower does (20 mg/kg); Ribavirin group; virus group and control group.The medicine treatment groups were injected intraperitoneally with equal volume solution starting from 60minutes after CVB3 were inoculated in the last time, the total days of administering medicine is for10 days.And control group were injected with 0.2ml of 0.9% sodium chloride instead of medicine. Six animals were killed in the 5th and the 10th day after administering medicine in each group for determination apoptosis (by Tunel method). Protein expression of Phospho-AktSer-473 were detected in the 10th day after treatment (by immunohistochemistry and Western Blot respectively). Results Compared with control group, apoptotic cells in virus group were increased (P＜0.05). The groups of Matrine treatment can significantly decrease apoptosis of myocardial tissue of VMC animals, and Matrine(40 mg/kg) can significantly increase phosphorylation of Aktser-473 in the myocardial tissue as compared with virus group. Conclusion Matrine can reduce myocardium apoptosis of VMC animals by promoting phosphorylation of AktSer-473 in the myocardial tissue to provides concrete protection against CVB3 infection.Key words: Myocarditis; Coxsackievirus infections; Apoptosis; Protein kinases; Matrine" @default.
- W3031334606 created "2020-06-05" @default.
- W3031334606 creator A5011450439 @default.
- W3031334606 creator A5050699240 @default.
- W3031334606 date "2010-08-30" @default.
- W3031334606 modified "2023-09-23" @default.
- W3031334606 title "Effects of matrine on akt protein expression in mice with viral myocarditis" @default.
- W3031334606 doi "https://doi.org/10.3760/cma.j.issn.1003-9279.2010.04.013" @default.
- W3031334606 hasPublicationYear "2010" @default.
- W3031334606 type Work @default.
- W3031334606 sameAs 3031334606 @default.
- W3031334606 citedByCount "0" @default.
- W3031334606 crossrefType "journal-article" @default.
- W3031334606 hasAuthorship W3031334606A5011450439 @default.
- W3031334606 hasAuthorship W3031334606A5050699240 @default.
- W3031334606 hasConcept C104317684 @default.
- W3031334606 hasConcept C118552586 @default.
- W3031334606 hasConcept C126322002 @default.
- W3031334606 hasConcept C16685009 @default.
- W3031334606 hasConcept C185592680 @default.
- W3031334606 hasConcept C190283241 @default.
- W3031334606 hasConcept C196795494 @default.
- W3031334606 hasConcept C203014093 @default.
- W3031334606 hasConcept C204232928 @default.
- W3031334606 hasConcept C2522874641 @default.
- W3031334606 hasConcept C2776408679 @default.
- W3031334606 hasConcept C2776415932 @default.
- W3031334606 hasConcept C2776545273 @default.
- W3031334606 hasConcept C2780040827 @default.
- W3031334606 hasConcept C2780875844 @default.
- W3031334606 hasConcept C2909190889 @default.
- W3031334606 hasConcept C31573885 @default.
- W3031334606 hasConcept C55493867 @default.
- W3031334606 hasConcept C66008609 @default.
- W3031334606 hasConcept C71924100 @default.
- W3031334606 hasConcept C75217442 @default.
- W3031334606 hasConcept C98274493 @default.
- W3031334606 hasConceptScore W3031334606C104317684 @default.
- W3031334606 hasConceptScore W3031334606C118552586 @default.
- W3031334606 hasConceptScore W3031334606C126322002 @default.
- W3031334606 hasConceptScore W3031334606C16685009 @default.
- W3031334606 hasConceptScore W3031334606C185592680 @default.
- W3031334606 hasConceptScore W3031334606C190283241 @default.
- W3031334606 hasConceptScore W3031334606C196795494 @default.
- W3031334606 hasConceptScore W3031334606C203014093 @default.
- W3031334606 hasConceptScore W3031334606C204232928 @default.
- W3031334606 hasConceptScore W3031334606C2522874641 @default.
- W3031334606 hasConceptScore W3031334606C2776408679 @default.
- W3031334606 hasConceptScore W3031334606C2776415932 @default.
- W3031334606 hasConceptScore W3031334606C2776545273 @default.
- W3031334606 hasConceptScore W3031334606C2780040827 @default.
- W3031334606 hasConceptScore W3031334606C2780875844 @default.
- W3031334606 hasConceptScore W3031334606C2909190889 @default.
- W3031334606 hasConceptScore W3031334606C31573885 @default.
- W3031334606 hasConceptScore W3031334606C55493867 @default.
- W3031334606 hasConceptScore W3031334606C66008609 @default.
- W3031334606 hasConceptScore W3031334606C71924100 @default.
- W3031334606 hasConceptScore W3031334606C75217442 @default.
- W3031334606 hasConceptScore W3031334606C98274493 @default.
- W3031334606 hasIssue "04" @default.
- W3031334606 hasLocation W30313346061 @default.
- W3031334606 hasOpenAccess W3031334606 @default.
- W3031334606 hasPrimaryLocation W30313346061 @default.
- W3031334606 hasRelatedWork W2333268705 @default.
- W3031334606 hasRelatedWork W2347972961 @default.
- W3031334606 hasRelatedWork W2352265072 @default.
- W3031334606 hasRelatedWork W2355283650 @default.
- W3031334606 hasRelatedWork W2355943476 @default.
- W3031334606 hasRelatedWork W2358220808 @default.
- W3031334606 hasRelatedWork W2361915006 @default.
- W3031334606 hasRelatedWork W2369090658 @default.
- W3031334606 hasRelatedWork W2370320143 @default.
- W3031334606 hasRelatedWork W2373528633 @default.
- W3031334606 hasRelatedWork W2373615850 @default.
- W3031334606 hasRelatedWork W2376074332 @default.
- W3031334606 hasRelatedWork W2376918848 @default.
- W3031334606 hasRelatedWork W2377014071 @default.
- W3031334606 hasRelatedWork W2378378149 @default.
- W3031334606 hasRelatedWork W2384675794 @default.
- W3031334606 hasRelatedWork W2388994614 @default.
- W3031334606 hasRelatedWork W2390966557 @default.
- W3031334606 hasRelatedWork W2394298908 @default.
- W3031334606 hasRelatedWork W3031913625 @default.
- W3031334606 hasVolume "24" @default.
- W3031334606 isParatext "false" @default.
- W3031334606 isRetracted "false" @default.
- W3031334606 magId "3031334606" @default.
- W3031334606 workType "article" @default.