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- W3031336475 abstract "Objective To explore the insult of gastroesophageal reflux (GER) on airway.Methods Ten Sprague-Dawley (SD) rats were randomly divided into group A and group B.Five New Zealand white rabbits were assigned to group C.A 9F catheter was inserted into the esophagus through animal's stomach under anesthesia.The thyroid and cricoid cartilages in group A were incised longitudinally.Five percent glucose and sodium chloride were injected into esophagus through a catheter in group A.For the first time,this study creates a high-located GER animal model and illustrates a morphology of pharyngeal nozzle and its spray phenomenon,which are the bases of GER in sult on airway and provide a new thinking for exploring the pathophysiological medianism of respiratory diseases caused by GER.Meglumine diatrizoate and 40％ barium sulfate were respectively injected into esophagus in groups B and C with pressure.The manifestation of pharynx and upper airway was observed under fluoroscopy and recorded by video.Results As injecting pressure increased in group A,spray with various parabola appeared from the distal pharynx.Pharyngeal nozzles were seen in groups B and C while the refluxing pressure increased to (150.0 ±9.8) mmHg (1 mmHg =0.133 kPa) and (187.8 ± 8.3) mmHg respectively.The animals gasped severely when the contrast agents entered instantly into the upper airway.Conclusion A high-located GER animal model is firstly created and it was confirmed that the pharyngeal nozzle and spray are the bases of GER insult on airway,which may provide a new thinking for exploring the pathophysiological machanism of respiratory diseases caused by GER.Key words: Gastroesophageal reflux ; Pharygeal nozzle ; Spray ; Respiratory disease; Asthma" @default.
- W3031336475 created "2020-06-05" @default.
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- W3031336475 date "2014-02-08" @default.
- W3031336475 modified "2023-09-24" @default.
- W3031336475 title "Pharyngeal nozzle and spray: gastroesophageal reflux insult on airway" @default.
- W3031336475 doi "https://doi.org/10.3760/cma.j.issn.1001-9030.2014.02.038" @default.
- W3031336475 hasPublicationYear "2014" @default.
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