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- W3031338929 abstract "ObjectiveTo evaluate the effect of dexmedetomidine on the cell apoptosis during the acute lung injury induced by blunt chest trauma in rats.MethodsThirty pathogen-free male Sprague-Dawley rats, weighing 240-270 g, aged 8 weeks, were divided into 3 groups(n=10 each)using a random number table: sham operation group(group Sham), blunt chest trauma group(group T)and blunt chest trauma plus dexmedetomidine group(group TD). The model of acute lung injury was induced by dropping a 300 g weight onto a precordium in anesthetized rats.After the model was established, dexmedetomidine was intravenously infused at a rate of 5 μg· kg-1·h-1 for 6 h in group TD.At 6 h after the model was established, blood samples were collected from the femoral artery for determination of concentrations of serum tumor necrosis factor-alpha(TNF-α)and interleukin-6(IL-6). The rats were sacrificed after blood sampling, and lungs were removed for examination of the pathological changes(with light microscope)and for determination of Bax and Bcl-2 expression in lung tissues(by immuno-histochemistry)and cell apoptosis(by TUNEL). Bcl-2/Bax ratio and apoptosis index(AI)were calculated.ResultsCompared with group C, the serum TNF-α and IL-6 concentrations and AI were significantly increased, the expression of Bax and Bcl-2 was up-regulated, and Bcl-2/Bax ratio was decreased in T and TD groups(P<0.01). Compared with group T, the serum TNF-α and IL-6 concentrations and AI were significantly decreased, the expression of Bax in lung tissues was down-regulated, the expression of Bcl-2 in lung tissues was up-regulated, Bcl-2/Bax ratio was increased(P<0.05), and the pathological changes of lung tissues were significantly attenuated in group TD.ConclusionThe mechanism by which dexmedetomidine mitigates the acute lung injury induced by blunt chest trauma is related to inhibition of cell apoptosis in rats.Key words: Dexmedetomidine; Respiratory distress syndrome, adult; Wounds and injuries; Apoptosis" @default.
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- W3031338929 date "2017-04-20" @default.
- W3031338929 modified "2023-09-23" @default.
- W3031338929 title "Effect of dexmedetomidine on cell apoptosis during acute lung injury induced by blunt chest trauma in rats" @default.
- W3031338929 doi "https://doi.org/10.3760/cma.j.issn.0254-1416.2017.04.024" @default.
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