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- W3031346128 abstract "Objective To investigate the effects of ionizing radiation on the expression of B-cell translocation gene 2 (BTG2) in cancer cells.Methods RT-PCR was used to determine the level of BTG2 mRNA,while the expression of BTG2 protein was assayed by Western blot.Results Compared with the unirradiated cells,a single dose of 3 Gy γ-rays caused a significant increase of BTG2 protein in breast cancer cell lines,MCF-7 and MDA-MB-231,and cervical cancer cell lines,C33A and HeLa.Furthermore,irradiation with γ-rays resulted in a dose and time dependent increase of BTG2 at both mRNA and protein levels.Conclusion The present study demonstrates,for the first time,that BTG2 is a value response gene to exposure of ionizing radiation,which may provide evidence for BTG2 as a novel marker for radiotherapy of cancer.Key words: Cancer; Radiation, ionizing; B-cell translocation gene 2" @default.
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- W3031346128 date "2014-03-25" @default.
- W3031346128 modified "2023-09-26" @default.
- W3031346128 title "Study on B-cell translocation gene 2 as a novel radiation-induced gene" @default.
- W3031346128 doi "https://doi.org/10.3760/cma.j.issn.1673-4114.2014.02.001" @default.
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