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- W3031382692 abstract "目的探讨白芍总苷对银屑病患者外周血单核细胞趋化蛋白-1(MCP-1)和巨噬细胞炎性蛋白-1α(MIP-1α)表达水平的影响及临床疗效。方法应用酶联免疫吸附试验(ELISA)检测40例寻常型银屑病患者白芍总苷治疗前、后外周血MCP-1和MIP-1α的水平,并与35例健康对照组比较;治疗8周后,以银屑病皮损面积及严重度指数(PASI)进行疗效评价。结果白芍总苷治疗银屑病患者8周后PASI评分下降明显,治疗前后差异有统计学意义(t=17.23,P<0.01);银屑病患者治疗前MCP-1、MIP-1α分别为(263.15±16.76)ng/L、(1397±169.32)ng/L,均明显高于对照组(t=32.6、33.27,均P<0.01);治疗后MCP-1、MIP-1α分别为(101.96±13.96)ng/L、(901±79.56)ng/L,治疗前后差异均有统计学意义(t=28.56、13.95,均P<0.01)。结论白芍总苷治疗银屑病效果明显,可能通过调节银屑病患者外周血MCP-1和MIP-1α的水平而达到治疗作用。" @default.
- W3031382692 created "2020-06-05" @default.
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- W3031382692 date "2019-02-15" @default.
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- W3031382692 title "Effect of total glucosides of paeony on MCP-1 and MIP-1α of the peripheral blood in patients with psoriasis vulgaris" @default.
- W3031382692 doi "https://doi.org/10.3760/cma.j.issn.1008-6706.2019.04.026" @default.
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