Matches in SemOpenAlex for { <https://semopenalex.org/work/W3031424884> ?p ?o ?g. }
Showing items 1 to 63 of
63
with 100 items per page.
- W3031424884 endingPage "51" @default.
- W3031424884 startingPage "48" @default.
- W3031424884 abstract "Objective To analyze the effect of tiotropium bromide on pulmonary function and airway remodeling in elder chronic obstructive pulmonary disease (COPD) stabilization patients.Methods Ninety-two elder patients diagnosed as COPD stabilization were divided into treatment group (50 patients) and control group (42 patients) by random digits table method.The patients in two groups were given basic treatment such as antimicrobial therapy,spasmolysis,antiasthma,expelling phlegm,and the patients in treatment group were given tiotropium bromide every day for 12 months besides the basic treatment.Meanwhile,40 healthy persons whose ages matched with those of COPD stabilization patients were as healthy control group.High resolution computerized tomography (HRCT) was employed to measure the parameters such as the airway wall thickness,the outer and inner diameter of the airway,airway wall area to assessed the airway remodeling before and after treatment in order to evaluate the drug etficacy.Meanwhile,the lung function,the inflammatory cytokines [interleukin (IL)-8,tumor necrosis factor (TNF)-α] in blood plasma and T lymphocyte subsets were also determined.Results The index of lung function in treatment group was significantly better than that before treatment and control group,and there was significant difference (P ＜ 0.05).The airway wall thickness in treatment group had no significant difference before and after treatment (P ＞0.05),and other index of airway remodeling was significantly improved compared with that before treatment (P ＜ 0.05).After treatment,the distance of 6 min walk test in treatment group was significantly longer than that in control group,and there was significant difference (P ＜ 0.05).The level of serum IL-8 and TNF-αt before treatment had no significant difference between two groups (P ＞0.05),and decreased significantly after treatment and the improvement was more pronounced in treatment group compared with that in control group (P ＜ 0.05).Compared with that in healthy control group,the level of CD3+,CD4+,CD4+/CD8+ was significantly lower and the level of CD8+ was significantly higher before treatment in treatment group and control group (P ＜ 0.05).After treatment,the level of CD3+,CD4+,CD4+/CD8+ was significantly increased and the level of CD8+ was significantly decreased (P ＜ 0.05),and the improvement was more pronounced in treatment group compared with that in control group (P ＜ 0.05).Conclusion Tiotropium bromide can improve airway remodeling and lung function in elder COPD stabilization patients.Key words: Pulmonary disease; chronic obstructive; Airway remodeling; Respiratory function tests; Tiotropium bromide" @default.
- W3031424884 created "2020-06-05" @default.
- W3031424884 creator A5009681320 @default.
- W3031424884 date "2014-08-05" @default.
- W3031424884 modified "2023-09-25" @default.
- W3031424884 title "Effect of tiotropium bromide on pulmonary function and airway remodeling in elder chronic obstructive pulmonary disease stabilization patients" @default.
- W3031424884 doi "https://doi.org/10.3760/cma.j.issn.1673-4904.2014.22.015" @default.
- W3031424884 hasPublicationYear "2014" @default.
- W3031424884 type Work @default.
- W3031424884 sameAs 3031424884 @default.
- W3031424884 citedByCount "1" @default.
- W3031424884 countsByYear W30314248842016 @default.
- W3031424884 crossrefType "journal-article" @default.
- W3031424884 hasAuthorship W3031424884A5009681320 @default.
- W3031424884 hasConcept C105922876 @default.
- W3031424884 hasConcept C126322002 @default.
- W3031424884 hasConcept C164705383 @default.
- W3031424884 hasConcept C2776780178 @default.
- W3031424884 hasConcept C2777714996 @default.
- W3031424884 hasConcept C42219234 @default.
- W3031424884 hasConcept C71924100 @default.
- W3031424884 hasConcept C75603125 @default.
- W3031424884 hasConcept C90924648 @default.
- W3031424884 hasConceptScore W3031424884C105922876 @default.
- W3031424884 hasConceptScore W3031424884C126322002 @default.
- W3031424884 hasConceptScore W3031424884C164705383 @default.
- W3031424884 hasConceptScore W3031424884C2776780178 @default.
- W3031424884 hasConceptScore W3031424884C2777714996 @default.
- W3031424884 hasConceptScore W3031424884C42219234 @default.
- W3031424884 hasConceptScore W3031424884C71924100 @default.
- W3031424884 hasConceptScore W3031424884C75603125 @default.
- W3031424884 hasConceptScore W3031424884C90924648 @default.
- W3031424884 hasIssue "22" @default.
- W3031424884 hasLocation W30314248841 @default.
- W3031424884 hasOpenAccess W3031424884 @default.
- W3031424884 hasPrimaryLocation W30314248841 @default.
- W3031424884 hasRelatedWork W2056247034 @default.
- W3031424884 hasRelatedWork W2353281220 @default.
- W3031424884 hasRelatedWork W2353675402 @default.
- W3031424884 hasRelatedWork W2360528741 @default.
- W3031424884 hasRelatedWork W2362988439 @default.
- W3031424884 hasRelatedWork W2364322441 @default.
- W3031424884 hasRelatedWork W2373800749 @default.
- W3031424884 hasRelatedWork W2376079253 @default.
- W3031424884 hasRelatedWork W2376881898 @default.
- W3031424884 hasRelatedWork W2379816580 @default.
- W3031424884 hasRelatedWork W2380052968 @default.
- W3031424884 hasRelatedWork W2382263665 @default.
- W3031424884 hasRelatedWork W2561477061 @default.
- W3031424884 hasRelatedWork W3029562276 @default.
- W3031424884 hasRelatedWork W3030741266 @default.
- W3031424884 hasRelatedWork W3031573158 @default.
- W3031424884 hasRelatedWork W3031809298 @default.
- W3031424884 hasRelatedWork W3032458071 @default.
- W3031424884 hasRelatedWork W3032775353 @default.
- W3031424884 hasRelatedWork W3032836008 @default.
- W3031424884 hasVolume "37" @default.
- W3031424884 isParatext "false" @default.
- W3031424884 isRetracted "false" @default.
- W3031424884 magId "3031424884" @default.
- W3031424884 workType "article" @default.