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- W3031454249 abstract "Purpose of the study was to evaluate the short-term efficacy and renal safety of meloxicam in patients with low back pain due to degenerative disk disease. Materials and methods. The study included 34 patients with low back pain who were receiving Meloxicam (in the form of rectal suppositories) in a dose of 15 mg per day for the period or 6 days and 20 healthy individuals who did not receive NSAIDs last year. We assessed the efficacy of the drug and renal safety (markers of kidney damage) over time. Results. The mean GFR in patients with degenerative disk disease was 68.5 (57.0; 83.0) ml/min/1.73 m 2 , in healthy individuals, the mean GFR was 88.4 (72.5; 99.5) ml/min/1.73 m 2 ( p = 0.0021); the urine albumin/creatinine ratio in patients with degenerative disk disease of the spine was 35.9 (20.9; 45.0) mg/g, in control group — 18.9 (17.3; 25.0) mg/g ( p = 0.0005); in patients high degree of microglobulinuria was established (94.0 (68.9, 137.1) mg/g) compared with the healthy individuals (12.5 (10.9; 13.2) mg/g), p = 0.0000. After the course of treatment, the patients revealed a reduction in the pain syndrome ( p < 0.01). Moreover, there was no deterioration in renal function and an increase in markers of kidney damage ( p ≥ 0.05). Conclusions. Meloxicam is an effective drug for reducing the intensity of the low back pain in patients with degenerative disk disease. Its administration is relatively safe in terms of development of nephrotoxicity in a short term perspective." @default.
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- W3031454249 date "2018-01-01" @default.
- W3031454249 modified "2023-09-27" @default.
- W3031454249 title "Efficacy and renal safety of Meloxicam in patients with degenerative disk disease: Results of the “Moment” scientific programm" @default.
- W3031454249 doi "https://doi.org/10.17816/mechnikov201810431-36" @default.
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