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- W3031455795 abstract "Objective To investigate the protective role of Xiongbitong capsule against liver injury in hyperlipemic rats.Methods Sixty Wistar male rats were randomly divided into 5 groups（12 rats in each group）： a blank group, a model group, a simvastatin group（10 mg/kg, 2 ml intragastric administration daily）, a Xiongbitong capsule high-dose group（25 mg/kg, 2 ml intragastric administration daily）, and a Xiongbitong capsule low-dose group（12.5 mg/kg, 2 ml intragastric administration daily）. Hyperlipidemia model in rats was indeuced by hyperlipidemic diet. The simvastatin group was intragastric administrated with simvastatin suspension 2 ml（10 mg/kg daily）, and the rats in the control group and the model group were intragastric administrated with equal volume of saline. After 10 weeks, the serum leves of total cholesterol（TC）, triacylglycerol（TG）, low-density lipoprotein cholesterol（LDL-C）, high-density lipoprotein cholesterol （HDL-C）, nitric oxide（NO）, endothelin1（ET-1）, and the whole blood viscosities（high-, medium-, low-shear）were measured. Liver injury were evaluated with histopathologic examination by H.E. staining. The expressions of intercellular adhesion molecule-1（ICAM-1）, monocyte chemoattractant protein-1（MCP-1）in hepatic tissue were measured by immunohistochemical staining.Results The serum leves of TC（1.47± 0.10 mmol/Lvs. 3.48±0.19 mmol/L）, TG（0.38±0.11 mmol/Lvs. 0.95±0.14 mmol/L）, LDL-C（1.48± 0.18 mmol/Lvs. 2.39±0.22 mmol/L）, ET-1（145.81±18.65 pg/mlvs. 177.70±17.70 pg/ml） in the Xiongbitong capsule high-dose group were significantly lower than those in the model group（allP〈0.01）, HDL-C（1.21±0.14 mmol/Lvs. 0.65±0.10 mmol/L）and NO（31.28±2.36μmol/Lvs. 19.61±1.28μmol/L） significantly lower than those in the model group（allP〈0.01）, the expressions of ICAM-1（0.133±0.019vs. 0.187±0.011）and MCP-1（0.153±0.014vs. 0.264±0.020）significantly lower than those in the model group（allP〈0.01）. The liver injury in the Xiongbitong capsule high-dose group decreased than that in the model group. Conclusions Xiongbitong capsule can protect against liver injury via regulating lipid metabolism, protecting endothelial function and down regulating expressions of MCP-1 and ICAM-1.Key words: Xiongbitong capsule; Hyperlipidemias; Endothelial cells; Nitric oxide; Monocyte chemoattractant proteins" @default.
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- W3031455795 date "2014-11-30" @default.
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- W3031455795 title "Protective effect of Xiongbitongcapsule on liver injury in hyperlipemic rats" @default.
- W3031455795 doi "https://doi.org/10.3760/cma.j.issn.1673-4246.2014.11.012" @default.
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