Matches in SemOpenAlex for { <https://semopenalex.org/work/W3031463911> ?p ?o ?g. }
Showing items 1 to 80 of
80
with 100 items per page.
- W3031463911 endingPage "1056" @default.
- W3031463911 startingPage "1054" @default.
- W3031463911 abstract "Objective To observe the antiangiogenesis of panaxoside-Rg3 on mice intraperitoneally implanted with ascites tlnnor cells.Methods 25 female and 25 male Kunming mice were random divided into five groups:Group I injected with normal saline (0.9%NS),Group Ⅱ with cisplatin(DDP 0.5mg/kg),Group Ⅲ,with low-dose panaxoside-Rg3(LPD 0.3mg/kg),Group Ⅳ with middle-dose panaxoside-Rg3(MPD 1.0mg/kg),Group Ⅴ with high-dose panaxoside-Rg3(HPD 3.0mg/kg).Experimental ascitic hepatocarcinoma of H22 lines model were successfully established among all groups,and 24 hours later intraperitoneal infusion of 0.2ml medicines was given to each mouse once every day for 14 days.24 hours after the over of the treatment,all mice were executed.Enzyme linked immunosorbent assay(ELISA)method was used to detectt he different VEGF level in the ascites and serum of all groups and expressions of micmvessel density (MVD)of peritoneum tumor node was calculated by immunohistochemical staining with CD31 antibody.Morphological of tumor cell in abdominal cavity and new vascular in peritoneum tumor node were observed by transmission electron microscope.Results With the increase of concentration of panaxoside-Rg3,expressions of the VEGF level of the ascites and the serum and MVD in peritoneum dropped(P＜0.05)and decreased more than that in the NS group and the DDP group(P＜0.05).Morphological changes of tumor ceHs in panaxoside-Rg3 group were observed with electronic scope,more apoptosis and necrosis cells were found.Capillary vessel basal lamina was smoothing.Condusion Panaxoside-Rg3 decreases the permeability of mierangium and inhibit the neovascula-rization of peritoneum by decreasing the VEGF level,accordingly,panaxoside-Rg3 inhibit the formation of malignant ascites.This would offer foundation of theory for clinical application.Key words: Ginsenoside/PD; Liver neoplasms; Ascites; Neovascularization,pathologic; Vascular endothelial growth factors" @default.
- W3031463911 created "2020-06-05" @default.
- W3031463911 creator A5036342258 @default.
- W3031463911 creator A5066921585 @default.
- W3031463911 date "2008-08-10" @default.
- W3031463911 modified "2023-09-25" @default.
- W3031463911 title "Antlangingenesis of panaxoside-Rg3 on ascitic-fluid type helmtocarcinoma H22 in mice" @default.
- W3031463911 doi "https://doi.org/10.3760/cma.j.issn.1008-1372.2008.08.015" @default.
- W3031463911 hasPublicationYear "2008" @default.
- W3031463911 type Work @default.
- W3031463911 sameAs 3031463911 @default.
- W3031463911 citedByCount "0" @default.
- W3031463911 crossrefType "journal-article" @default.
- W3031463911 hasAuthorship W3031463911A5036342258 @default.
- W3031463911 hasAuthorship W3031463911A5066921585 @default.
- W3031463911 hasConcept C105702510 @default.
- W3031463911 hasConcept C126322002 @default.
- W3031463911 hasConcept C142724271 @default.
- W3031463911 hasConcept C16685009 @default.
- W3031463911 hasConcept C185592680 @default.
- W3031463911 hasConcept C190283241 @default.
- W3031463911 hasConcept C204232928 @default.
- W3031463911 hasConcept C2776001837 @default.
- W3031463911 hasConcept C2776694085 @default.
- W3031463911 hasConcept C2777397205 @default.
- W3031463911 hasConcept C2778239845 @default.
- W3031463911 hasConcept C2778939058 @default.
- W3031463911 hasConcept C2780159080 @default.
- W3031463911 hasConcept C2780496750 @default.
- W3031463911 hasConcept C2780936613 @default.
- W3031463911 hasConcept C55493867 @default.
- W3031463911 hasConcept C71924100 @default.
- W3031463911 hasConceptScore W3031463911C105702510 @default.
- W3031463911 hasConceptScore W3031463911C126322002 @default.
- W3031463911 hasConceptScore W3031463911C142724271 @default.
- W3031463911 hasConceptScore W3031463911C16685009 @default.
- W3031463911 hasConceptScore W3031463911C185592680 @default.
- W3031463911 hasConceptScore W3031463911C190283241 @default.
- W3031463911 hasConceptScore W3031463911C204232928 @default.
- W3031463911 hasConceptScore W3031463911C2776001837 @default.
- W3031463911 hasConceptScore W3031463911C2776694085 @default.
- W3031463911 hasConceptScore W3031463911C2777397205 @default.
- W3031463911 hasConceptScore W3031463911C2778239845 @default.
- W3031463911 hasConceptScore W3031463911C2778939058 @default.
- W3031463911 hasConceptScore W3031463911C2780159080 @default.
- W3031463911 hasConceptScore W3031463911C2780496750 @default.
- W3031463911 hasConceptScore W3031463911C2780936613 @default.
- W3031463911 hasConceptScore W3031463911C55493867 @default.
- W3031463911 hasConceptScore W3031463911C71924100 @default.
- W3031463911 hasIssue "08" @default.
- W3031463911 hasLocation W30314639111 @default.
- W3031463911 hasOpenAccess W3031463911 @default.
- W3031463911 hasPrimaryLocation W30314639111 @default.
- W3031463911 hasRelatedWork W2351952608 @default.
- W3031463911 hasRelatedWork W2353402185 @default.
- W3031463911 hasRelatedWork W2355511997 @default.
- W3031463911 hasRelatedWork W2356481950 @default.
- W3031463911 hasRelatedWork W2359170993 @default.
- W3031463911 hasRelatedWork W2361006437 @default.
- W3031463911 hasRelatedWork W2361402184 @default.
- W3031463911 hasRelatedWork W2366271449 @default.
- W3031463911 hasRelatedWork W2367644126 @default.
- W3031463911 hasRelatedWork W2368868365 @default.
- W3031463911 hasRelatedWork W2371064388 @default.
- W3031463911 hasRelatedWork W2372595520 @default.
- W3031463911 hasRelatedWork W2373046511 @default.
- W3031463911 hasRelatedWork W2376976586 @default.
- W3031463911 hasRelatedWork W2377591479 @default.
- W3031463911 hasRelatedWork W2388762021 @default.
- W3031463911 hasRelatedWork W2389789178 @default.
- W3031463911 hasRelatedWork W2392175189 @default.
- W3031463911 hasRelatedWork W2491501156 @default.
- W3031463911 hasRelatedWork W3030032982 @default.
- W3031463911 hasVolume "10" @default.
- W3031463911 isParatext "false" @default.
- W3031463911 isRetracted "false" @default.
- W3031463911 magId "3031463911" @default.
- W3031463911 workType "article" @default.