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- W3031473669 abstract "目的 探讨低蛋白对大鼠出生体重影响的关键时间、成年后是否出现多种激素抵抗以及各自的特点.方法 妊娠鼠随机分为五组(每组12只):正常对照组、妊娠早期低蛋白组、妊娠中期低蛋白组、妊娠晚期低蛋白组以及全程低蛋白组,足月自然分娩后观察新生鼠体重及数目.再以各组小于孕龄(small for gestational age,SGA)鼠为研究对象(每组9只),于生后12周时测体重(bodyweight,BW),双侧肾周脂重(fat weight,FW),计算Fw/Bw;并采用ELISA法测定血糖、胰岛素及瘦素,计算胰岛素敏感指数(insulin sentivity index,ISI). 结果 早期低蛋白饮食组所分娩的新生鼠平均体重(8.72±0.51)g,与正常对照组(7.10±0.62)g比较显著升高(P＜0.05);全程低蛋白饮食组所分娩的新生鼠数目明显减少,且体重(4.87±0.3)g明显低于正常对照组(P均＜0.01).晚期低蛋白组大鼠生后12周时体重(6.79±0.56)g升高但无统计学意义(P＞0.05),但胰岛素、瘦素[分别为(4.96±2.11)μg/L和(6.36±0.68)μg/L]升高及ISI(4.29±0.18)水平明显降低(P＜0.05),而全程低蛋白组鼠体重(223.64±17.91)g、肾周脂重(2.36±1.51)g及FW/BW(11.03±6.17)‰、胰岛素、瘦素水平升高[分别为(5.43±1.32)μg/L、(8.07±0.91)μg/L],而ISI(3.91±0.42)低于对N～I(P＜0.05或＜0.01).结论 妊娠早期低蛋白可能导致出生体重的增加,全程低蛋白导致低出生体重;妊娠晚期的低蛋白及全程低蛋白引起的低出生体重鼠在成年后更容易发生胰岛素及瘦素的抵抗。" @default.
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- W3031473669 date "2007-09-16" @default.
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- W3031473669 title "Effects of low dietary protein in different trimester on adult hormone resistance in the offspings of rats" @default.
- W3031473669 doi "https://doi.org/10.3760/cma.j.issn.1007-9408.2007.05.008" @default.
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