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- W3031476311 abstract "ObjectiveTo compare the curative effect with high frequent oscillation ventilation (HFOV) and with HFOV+ inhaled nitric oxide(iNO) in the treatment of neonatal hypoxic respiratory failure(NRHF).MethodsData of 60 NHRF patients in the People′s Hospital of Dehong Prefecture from January 2015 to December 2016 were retrospectively analyzed.The patients were divided into HFOV group (32 cases) and HFOV+ iNO group (28 cases) according to the treatment methods.The comparison between the 2 groups was established as following: oxygenation index(OI), arterial partial pressure of carbon dioxide[pa(CO2)] and complications.ResultsThere was no significant difference between the 2 groups in time of birth, gestational age, birth weight, gender ratio and original diseases(all P>0.05). As for OI there was no significant difference at 0 h between the 2 groups(27.8±3.5 vs. 27.6±3.7)(t=0.04, P>0.05); OI of HFOV+ iNO group (11.2±3.4, 7.3±3.0, 7.0±2.6, respectively) was more significantly decreased than that in the HFOV group (14.5±3.3, 9.6±3.0, 8.5±2.8, respectively) at 8 h, 16 h, 24 h, and there were significant differences between the 2 groups(t=3.81, 5.16, 2.14, all P 0.05); the changes in pa(CO2) had no statistically significance difference between HFOV+ iNO group and HFOV group at 8 h, 16 h, 24 h[8 h: (50.71±10.49) mmHg vs.(49.02±11.74) mmHg, 16 h: (40.99±12.38) mmHg vs.(40.02±12.04) mmHg, and 24 h: (39.01±9.80) mmHg vs.(38.00±7.85) mmHg, all P>0.05]. As for the complications, there was no difference between the 2 groups in pulmonary air leak, pneumorrhagia, intracranial hemorrhage, blood platelet 3%, or dysfunction of blood coagulation (all P>0.05).ConclusionBoth HFOV and HFOV+ iNO methods are effective for NRHF.Treatment with HFOV+ iNO method is more effective.Treatment for NHRF with HFOV+ iNO is safe, effective, without complication increase in a short term.Key words: Inhaled nitric oxide; High frequent oscillation ventilation; Respiratory failure; Infant, newborn" @default.
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- W3031476311 date "2017-09-20" @default.
- W3031476311 modified "2023-09-24" @default.
- W3031476311 title "Analysis of curative effect of high frequent oscillation ventilation combined with inhaled nitric oxide for neonatal hypoxic respiratory failure" @default.
- W3031476311 doi "https://doi.org/10.3760/cma.j.issn.2095-428x.2017.18.011" @default.
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