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- W3031508759 abstract "Objective To study the regularity of the trophic and differentiated effects of the bone marrow mesenchymal stem cells(MSCs).Methods An in vivo model was established to investigate the trophic and differentiated effects of MSCs that were cultured in vitro,labeled with GFP,and transplanted to the model at a density of 5×106 cells/ml.By the 1st,2nd,4th,and 8th week,immunofluorescence and confocal laser scanning microscopy were used to evaluate the regularity of the TGF-β1,IGF-1,HIF-1α,and colben type Ⅱ.Results By the 2nd week,the positive percentages of TGF-1 and IGF-1 were increased to the peak value,(22.68±6.83)% and(35.67±6.56)% respectively,and then descended.The HIF-1α and collagen type Ⅱ were inereased from the 1st week to 8th week with no interruption,and the positive percentages were(55.35±14.06)% and(37.23±9.53)% respectively by the 8th week.The amplification was largest from the 2nd to 4th week.Conclusion The trophic effects play a major part in early(2nd week)regeneration,and differentiated effects play a major part in later regeneration after 4th week.Key words: Intervertebral disc degeneration; Bone marrow mesenchymal stem cells; Trans plantation; Differentiated effects" @default.
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- W3031508759 date "2009-06-08" @default.
- W3031508759 modified "2023-09-26" @default.
- W3031508759 title "The rise and fall of the trophic and differentiated effects in cell therapy for regeneration of degenerative intervertebral discs" @default.
- W3031508759 doi "https://doi.org/10.3760/cma.j.issn.1001-9030.2009.06.009" @default.
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