FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3031513807> ?p ?o ?g. }

• W3031513807 abstract "The COVID-19 pandemic has had major negative health, psychological, social and economic repercussions for individuals, families, communities, countries and for humanity in general. The interrelation with age and the presence of chronic non-communicable diseases (hypertension, diabetes, obesity, smoking) seems to go further than what would be explained by the prevalence and distribution of both. The drugs that act on the renin-angiotensin-aldosterone system are in many cases the backbone for the management of these diseases, it has been known for a long time that these drugs significantly increase the expression of receptors for angiotensin conversion enzyme type 2 in the lung tissue. This fact, together with the knowledge that the route of entry of the virus into the cell is precisely the ACE-2 receptor, initiated a hypothesis, based on very low-quality evidence, which quickly became generalized in the media, that the use of these drugs could be negative and that they should be interrupted immediately. The response of practically all Scientific Societies was almost immediate, with the precise indication that treatment with these drugs should not be discontinued, since the evidence of their usefulness is based on very solid and high-quality evidence. Simultaneously, a different hypothesis also appeared, also based on very preliminary evidence, that these drugs are not only harmful but also beneficial, however these medicaments are not yet accepted as agents for the prevention or treatment of this disease or its complications. This review reports current knowledge on the relationship between COVID-19 and SRAA.La pandemia por COVID-19 ha tenido muy importantes repercusiones negativas, sanitarias, psicológicas, sociales y económicas para las personas, las familias, las comunidades, los países y para las para la humanidad en general. La interrelación con la edad y la presencia de enfermedades crónicas no trasmisibles (hipertensión, diabetes, obesidad, tabaquismo) parece ir mas lejos que lo que explicaría la prevalencia y distribución de ambas. Los medicamentos que actúan sobre el sistema renina-angiotensina-aldosterona, son pilares básicos en el manejo de estas enfermedades. Se sabe de tiempo atrás que estos fármacos aumentan en forma significativa la expresión en el tejido pulmonar de receptores para la enzima de conversión de angiotensina de tipo 2. Este hecho junto con el conocimiento de que la vía de entrada del virus a la célula es precisamente el receptor de ECA-2, inició una hipótesis, basada en evidencia de muy baja calidad, que rápidamente se generalizó en los medios de comunicación, de que el empleo de estos medicamentos podría ser negativo y que deberían suspenderse. La respuesta de prácticamente todas las sociedades científicas fue casi inmediata, con la indicación precisa de que no debería suspenderse el tratamiento con estos fármacos, puesto que la evidencia de su utilidad está basada en una evidencia muy sólida y de gran calidad. Casi simultáneamente también apareció la hipótesis, también basada en evidencia muy preliminar, de que estos medicamentos no solo resultan dañinos sino que son benéficos, tampoco se aceptan todavía como agentes para la prevención o tratamiento de esta enfermedad o sus complicaciones. La presente revisión relata los conocimientos actuales sobre la relación entre COVID-19 y SRAA." @default.
• W3031513807 created "2020-06-05" @default.
• W3031513807 creator A5000783597 @default.
• W3031513807 creator A5017272773 @default.
• W3031513807 creator A5028756215 @default.
• W3031513807 creator A5029573438 @default.
• W3031513807 creator A5039402369 @default.
• W3031513807 creator A5050143334 @default.
• W3031513807 creator A5081067839 @default.
• W3031513807 date "2021-09-30" @default.
• W3031513807 modified "2023-09-23" @default.
• W3031513807 title "COVID-19 y el sistema renina, angiotensina, aldosterona. Una relación compleja" @default.
• W3031513807 cites W2028521865 @default.
• W3031513807 cites W2091671824 @default.
• W3031513807 cites W2109679166 @default.
• W3031513807 cites W2159821964 @default.
• W3031513807 cites W3001897055 @default.
• W3031513807 cites W3004348779 @default.
• W3031513807 cites W3007643904 @default.
• W3031513807 cites W3012285389 @default.
• W3031513807 cites W3013871850 @default.
• W3031513807 cites W3016248990 @default.
• W3031513807 doi "https://doi.org/10.24875/acm.m20000063" @default.
• W3031513807 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32523145" @default.
• W3031513807 hasPublicationYear "2021" @default.
• W3031513807 type Work @default.
• W3031513807 sameAs 3031513807 @default.
• W3031513807 citedByCount "4" @default.
• W3031513807 countsByYear W30315138072020 @default.
• W3031513807 countsByYear W30315138072021 @default.
• W3031513807 countsByYear W30315138072022 @default.
• W3031513807 countsByYear W30315138072023 @default.
• W3031513807 crossrefType "journal-article" @default.
• W3031513807 hasAuthorship W3031513807A5000783597 @default.
• W3031513807 hasAuthorship W3031513807A5017272773 @default.
• W3031513807 hasAuthorship W3031513807A5028756215 @default.
• W3031513807 hasAuthorship W3031513807A5029573438 @default.
• W3031513807 hasAuthorship W3031513807A5039402369 @default.
• W3031513807 hasAuthorship W3031513807A5050143334 @default.
• W3031513807 hasAuthorship W3031513807A5081067839 @default.
• W3031513807 hasBestOaLocation W30315138071 @default.
• W3031513807 hasConcept C126322002 @default.
• W3031513807 hasConcept C177713679 @default.
• W3031513807 hasConcept C198710026 @default.
• W3031513807 hasConcept C2779134260 @default.
• W3031513807 hasConcept C3008058167 @default.
• W3031513807 hasConcept C524204448 @default.
• W3031513807 hasConcept C71924100 @default.
• W3031513807 hasConcept C84393581 @default.
• W3031513807 hasConcept C89623803 @default.
• W3031513807 hasConceptScore W3031513807C126322002 @default.
• W3031513807 hasConceptScore W3031513807C177713679 @default.
• W3031513807 hasConceptScore W3031513807C198710026 @default.
• W3031513807 hasConceptScore W3031513807C2779134260 @default.
• W3031513807 hasConceptScore W3031513807C3008058167 @default.
• W3031513807 hasConceptScore W3031513807C524204448 @default.
• W3031513807 hasConceptScore W3031513807C71924100 @default.
• W3031513807 hasConceptScore W3031513807C84393581 @default.
• W3031513807 hasConceptScore W3031513807C89623803 @default.
• W3031513807 hasIssue "91" @default.
• W3031513807 hasLocation W30315138071 @default.
• W3031513807 hasLocation W30315138072 @default.
• W3031513807 hasOpenAccess W3031513807 @default.
• W3031513807 hasPrimaryLocation W30315138071 @default.
• W3031513807 hasRelatedWork W3103289217 @default.
• W3031513807 hasRelatedWork W3106370311 @default.
• W3031513807 hasRelatedWork W3108360120 @default.
• W3031513807 hasRelatedWork W3119540162 @default.
• W3031513807 hasRelatedWork W3152606407 @default.
• W3031513807 hasRelatedWork W3152916563 @default.
• W3031513807 hasRelatedWork W4313474620 @default.
• W3031513807 hasRelatedWork W4327956415 @default.
• W3031513807 hasRelatedWork W4381432928 @default.
• W3031513807 hasRelatedWork W4381942459 @default.
• W3031513807 hasVolume "90" @default.
• W3031513807 isParatext "false" @default.
• W3031513807 isRetracted "false" @default.
• W3031513807 magId "3031513807" @default.
• W3031513807 workType "article" @default.