Matches in SemOpenAlex for { <https://semopenalex.org/work/W3031542233> ?p ?o ?g. }
Showing items 1 to 68 of
68
with 100 items per page.
- W3031542233 endingPage "628" @default.
- W3031542233 startingPage "623" @default.
- W3031542233 abstract "Cervical cancer is the second most common cancer in women worldwide. It is clear that persistent infection of high-risk human papillomaviruses (HR-HPVs) is the main cause for this disease. Among the several HPV types associated with carcinoma, HPV-16 is the most prevalent type and present in about 50% of tumor specimens. The major capsid protein (L1) of HPV can self-assemble into virus-like particles (VLPs) with immunogenicity similar to infectious virions. Neutralizing epitopes are the structural basis of the current prophylactic HPV vaccines. The efficacy of HPV vaccines is critically dependent upon the integrity of type-specific neutralizing epitopes. Recently, considerable headway has been made in studying the epitopes of HPV16 based on neutralizing antibodies. Notably, more and more HPV16 variants have appeared along with increasing immune pressure. To study the phenotypic variations in HPV16 L1 protein, 1 204 naturally occurring sequences were analyzed and a phylogenetic tree was then constructed including four clades. Moreover, after compared the aforementioned sequences with the 114K reference sequence, eight hot mutation sites , six specialized mutation sites and 20 epitope-related mutation sites were found. Generally, sera raised against VLPs can neutralize the corresponding HPV types, but not other types. However, it is not known whether intragenotypic variants of human papillomavirus type 16 (HPV-16) can be neutralized by sera vaccinated with a single variant VLPs. It is, therefore, imperative to understand the neutralizing epitopes and intragenotypic variants of HPV-16 for the production of prophylactic vaccines with high potency and broad coverage.Key words: Human papillomavirus; Major capsid protein; Amino acid substitution; Neutralizing epitope; Variant" @default.
- W3031542233 created "2020-06-05" @default.
- W3031542233 creator A5027810140 @default.
- W3031542233 creator A5053559346 @default.
- W3031542233 creator A5069222966 @default.
- W3031542233 creator A5076011780 @default.
- W3031542233 date "2018-08-31" @default.
- W3031542233 modified "2023-09-26" @default.
- W3031542233 title "Neutralizing epitopes and intragenotypic variants of human papillomavirus 16 (HPV16)" @default.
- W3031542233 doi "https://doi.org/10.3760/cma.j.issn.0254-5101.2018.08.011" @default.
- W3031542233 hasPublicationYear "2018" @default.
- W3031542233 type Work @default.
- W3031542233 sameAs 3031542233 @default.
- W3031542233 citedByCount "0" @default.
- W3031542233 crossrefType "journal-article" @default.
- W3031542233 hasAuthorship W3031542233A5027810140 @default.
- W3031542233 hasAuthorship W3031542233A5053559346 @default.
- W3031542233 hasAuthorship W3031542233A5069222966 @default.
- W3031542233 hasAuthorship W3031542233A5076011780 @default.
- W3031542233 hasConcept C159047783 @default.
- W3031542233 hasConcept C159654299 @default.
- W3031542233 hasConcept C195616568 @default.
- W3031542233 hasConcept C202878990 @default.
- W3031542233 hasConcept C2522874641 @default.
- W3031542233 hasConcept C2779261636 @default.
- W3031542233 hasConcept C2780868878 @default.
- W3031542233 hasConcept C54355233 @default.
- W3031542233 hasConcept C86803240 @default.
- W3031542233 hasConceptScore W3031542233C159047783 @default.
- W3031542233 hasConceptScore W3031542233C159654299 @default.
- W3031542233 hasConceptScore W3031542233C195616568 @default.
- W3031542233 hasConceptScore W3031542233C202878990 @default.
- W3031542233 hasConceptScore W3031542233C2522874641 @default.
- W3031542233 hasConceptScore W3031542233C2779261636 @default.
- W3031542233 hasConceptScore W3031542233C2780868878 @default.
- W3031542233 hasConceptScore W3031542233C54355233 @default.
- W3031542233 hasConceptScore W3031542233C86803240 @default.
- W3031542233 hasIssue "8" @default.
- W3031542233 hasLocation W30315422331 @default.
- W3031542233 hasOpenAccess W3031542233 @default.
- W3031542233 hasPrimaryLocation W30315422331 @default.
- W3031542233 hasRelatedWork W1965284004 @default.
- W3031542233 hasRelatedWork W1973749450 @default.
- W3031542233 hasRelatedWork W1985584979 @default.
- W3031542233 hasRelatedWork W1990223055 @default.
- W3031542233 hasRelatedWork W1994718680 @default.
- W3031542233 hasRelatedWork W2009115624 @default.
- W3031542233 hasRelatedWork W2030039892 @default.
- W3031542233 hasRelatedWork W2068465897 @default.
- W3031542233 hasRelatedWork W2069794080 @default.
- W3031542233 hasRelatedWork W2073040112 @default.
- W3031542233 hasRelatedWork W2079442139 @default.
- W3031542233 hasRelatedWork W2086463570 @default.
- W3031542233 hasRelatedWork W2125139555 @default.
- W3031542233 hasRelatedWork W2137343761 @default.
- W3031542233 hasRelatedWork W2160808472 @default.
- W3031542233 hasRelatedWork W2603764459 @default.
- W3031542233 hasRelatedWork W2758967495 @default.
- W3031542233 hasRelatedWork W2910113887 @default.
- W3031542233 hasRelatedWork W2969071561 @default.
- W3031542233 hasRelatedWork W3088524311 @default.
- W3031542233 hasVolume "38" @default.
- W3031542233 isParatext "false" @default.
- W3031542233 isRetracted "false" @default.
- W3031542233 magId "3031542233" @default.
- W3031542233 workType "article" @default.