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- W3031544751 abstract "Recent studies have shown that biological agents are evidently effective for the treatment of refractory pemphigus and pemphigoid.Rituximab,a monoclonal human/mouse chimeric IgG1 antibody targeting the B-cell specific cell-surface antigen CD20,is the earliest and most widely used biological agent for pemphigus and pemphigoid.Besides rituximab,other agents such as infliximab,P38 mitogen activated protein kinase (MAPK) inhibitor KC706,PI-0824 vaccine and blockers of or monoclonal antibodies against tumor necrosis factor also have exhibited favorable effects.However,potentially serious adverse reactions,high expense and lack of reliable clinical data have limited the wide application of biological agents in the treatment of pemphigus and pemphigoid.Key words: Pemphigus; Pemphigoid, bullous; Biological products; Therapy" @default.
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- W3031544751 date "2014-01-15" @default.
- W3031544751 modified "2023-09-23" @default.
- W3031544751 title "Application of biological agents in pemphigus and bullous pemphigoid" @default.
- W3031544751 doi "https://doi.org/10.3760/cma.j.issn.1673-4173.2014.01.025" @default.
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