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• W3031546681 abstract "Chimeric antigen receptor-modified (CAR) T cells targeting CD19 have revolutionized the treatment of relapsed or refractory aggressive B-cell lymphomas, and their use has increased the cure rate for these cancers from 10 to 40%. Two second-generation anti-CD19 CAR T-cell products, axicabtagene ciloleucel and tisagenlecleucel, have been approved for use in patients, and the approval of a third product, lisocabtagene maraleucel, is expected in 2020. The commercial availability of the first two products has facilitated the development of real-world experience in treating relapsed or refractory aggressive B-cell lymphomas, shed light on anti-CD19 CAR T-cell products' feasibility in trial-ineligible patients, and raised the need for strategies to mitigate the adverse effects associated with anti-CD19 CAR T-cell therapy, such as cytokine release syndrome, neurotoxicity, and cytopenia. In addition, promising clinical data supporting the use of anti-CD19 CAR T-cell therapy in patients with indolent B-cell lymphomas or chronic lymphocytic leukemia have recently become available, breaking the paradigm that these conditions are not curable. Multiple clinical CAR T-cell therapy-based trials are ongoing. These include studies comparing CAR T-cell therapy to autologous stem cell transplantation or investigating their use at earlier stages of disease, novel combinations, and novel constructs. Here we provide a thorough review on the use of the anti-CD19 CAR T-cell products axicabtagene ciloleucel, tisagenlecleucel and lisocabtagene maraleucel in patients with indolent or aggressive B-cell lymphoma or with chronic lymphocytic leukemia, and present novel CAR T cell-based approaches currently under investigation in these disease settings." @default.
• W3031546681 created "2020-06-05" @default.
• W3031546681 creator A5004429478 @default.
• W3031546681 creator A5038196228 @default.
• W3031546681 date "2020-05-27" @default.
• W3031546681 modified "2023-10-14" @default.
• W3031546681 title "CAR T-Cell Therapy for B-Cell non-Hodgkin Lymphoma and Chronic Lymphocytic Leukemia: Clinical Trials and Real-World Experiences" @default.
• W3031546681 cites W1619537825 @default.
• W3031546681 cites W1963522404 @default.
• W3031546681 cites W1965498936 @default.
• W3031546681 cites W1971424591 @default.
• W3031546681 cites W1991890073 @default.
• W3031546681 cites W2003197307 @default.
• W3031546681 cites W2051549641 @default.
• W3031546681 cites W2057389857 @default.
• W3031546681 cites W2063218301 @default.
• W3031546681 cites W2084647551 @default.
• W3031546681 cites W2089103836 @default.
• W3031546681 cites W2104187048 @default.
• W3031546681 cites W2144491853 @default.
• W3031546681 cites W2145985838 @default.
• W3031546681 cites W2167550136 @default.
• W3031546681 cites W2170513194 @default.
• W3031546681 cites W2219506342 @default.
• W3031546681 cites W2283468082 @default.
• W3031546681 cites W2296829012 @default.
• W3031546681 cites W2301169192 @default.
• W3031546681 cites W2322790172 @default.
• W3031546681 cites W2343067948 @default.
• W3031546681 cites W2413807845 @default.
• W3031546681 cites W2509364267 @default.
• W3031546681 cites W2514418134 @default.
• W3031546681 cites W2566677727 @default.
• W3031546681 cites W2583070206 @default.
• W3031546681 cites W2592521826 @default.
• W3031546681 cites W2595237007 @default.
• W3031546681 cites W2595477151 @default.
• W3031546681 cites W2602369513 @default.
• W3031546681 cites W2693970509 @default.
• W3031546681 cites W2734526350 @default.
• W3031546681 cites W2735691291 @default.
• W3031546681 cites W2737070795 @default.
• W3031546681 cites W2738977754 @default.
• W3031546681 cites W2754562068 @default.
• W3031546681 cites W2765978780 @default.
• W3031546681 cites W2766229434 @default.
• W3031546681 cites W2769769460 @default.
• W3031546681 cites W2773065484 @default.
• W3031546681 cites W2773804840 @default.
• W3031546681 cites W2775369717 @default.
• W3031546681 cites W2793744535 @default.
• W3031546681 cites W2793787928 @default.
• W3031546681 cites W2801641802 @default.
• W3031546681 cites W2808493395 @default.
• W3031546681 cites W2886502012 @default.
• W3031546681 cites W2888019042 @default.
• W3031546681 cites W2890039919 @default.
• W3031546681 cites W2891496270 @default.
• W3031546681 cites W2892311750 @default.
• W3031546681 cites W2892326722 @default.
• W3031546681 cites W2893050608 @default.
• W3031546681 cites W2895341625 @default.
• W3031546681 cites W2899173439 @default.
• W3031546681 cites W2900191251 @default.
• W3031546681 cites W2900884053 @default.
• W3031546681 cites W2901026782 @default.
• W3031546681 cites W2903062212 @default.
• W3031546681 cites W2903225254 @default.
• W3031546681 cites W2904192212 @default.
• W3031546681 cites W2905654445 @default.
• W3031546681 cites W2906376650 @default.
• W3031546681 cites W2906492823 @default.
• W3031546681 cites W2906766510 @default.
• W3031546681 cites W2906996236 @default.
• W3031546681 cites W2907012610 @default.
• W3031546681 cites W2907015766 @default.
• W3031546681 cites W2907417639 @default.
• W3031546681 cites W2907979442 @default.
• W3031546681 cites W2907979991 @default.
• W3031546681 cites W2908102421 @default.
• W3031546681 cites W2910655165 @default.
• W3031546681 cites W2910778868 @default.
• W3031546681 cites W2911254867 @default.
• W3031546681 cites W2911771159 @default.
• W3031546681 cites W2912558275 @default.
• W3031546681 cites W2917035693 @default.
• W3031546681 cites W2919004412 @default.
• W3031546681 cites W2922286357 @default.
• W3031546681 cites W2934961572 @default.
• W3031546681 cites W2945824414 @default.
• W3031546681 cites W2946307588 @default.
• W3031546681 cites W2947031696 @default.
• W3031546681 cites W2947160894 @default.
• W3031546681 cites W2947312151 @default.
• W3031546681 cites W2949916213 @default.
• W3031546681 cites W2950789181 @default.
• W3031546681 cites W2950868969 @default.
• W3031546681 cites W2952842269 @default.
• W3031546681 cites W2953001506 @default.
• W3031546681 cites W2953462331 @default.

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