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- W3031567184 abstract "ObjectiveTo explore the relationship between the expression of Toll-like receptor 4(TLR4) and forkhead/winged helix transcription factor P3(Foxp3) in cutaneous malignant melanoma(CMM)and the role of TLR4 in immune evasion.MethodsImmunohistochemistry was used to detect the expression of TLR4 and Foxp3 in 42 cases of CMM, 36 cases of pigmented nevus and 30 cases of normal skin specimens.Lipopolysaccharide(LPS) was employed as exogenous ligands to activate TLR4 in A375 cells.The m RNA and protein levels of Foxp3 were detected by reverse transcriptase-polymerase chain reaction(RT-PCR) and Western blotting.Specific TLR4 small interfering RNA(siRNA) was synthesized and transfected into A375 cells by lentivirus. The expression of Foxp3 and the proliferation of CD4+ CD25- T lymphocytes were examined.ResultsThe positive expression rate of TLR4 and Foxp3 in CMM(66. 7% and 95. 2%) was significantly higher than in the pigmented nevus(41. 7% and 11. 1%) and normal skin(16. 7% and 0%)(P< 0. 05), and they were positively correlated(r= 0. 883,P< 0. 05).The expression of Foxp3 at mRNA and protein levels was significantly increased by LPS stimulation.siRNA could suppress the expression level of Foxp3 and down-regulate the inhibitory ability of tumor cells on the proliferation of CD4+ CD25- T lymphocytes(P< 0. 05).ConclusionTLR4 signaling pathway may be involved in CMM immune evasion process by upregulating Foxp3 expression.Key words: Malignant melanoma; Toll-like receptor 4; Forkhead/winged helix transcription factor P3; Immune evasion" @default.
- W3031567184 created "2020-06-05" @default.
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- W3031567184 date "2015-06-08" @default.
- W3031567184 modified "2023-09-24" @default.
- W3031567184 title "Expression of Toll-like receptor 4 in cutaneous malignant melanoma and its mechanism in the process of cutaneous malignant melanoma immune evasion" @default.
- W3031567184 doi "https://doi.org/10.3760/cma.j.issn.1001-9030.2015.06.063" @default.
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