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- W3031570474 abstract "ObjectiveTo observe effect of Trim28 (ser473) phosphorylation on viability of hepatocellular carcinoma (HCC) cells during DNA damage.MethodsTo divide Hepg2 cells into 2 groups as SB203580+ UV group and UV group. Hepg2 cells were modeled for DNA damage by UV (Ultraviolet) irradiation. SB203580+ UV group was treated with Trim28 phosphorylation inhibitor SB203580 after UV irradiation. Expression of Trim28 and phosphorylation-Trim28 ser473 (P-Trim28 ser473)were detected by westernblot experiment. The viability of Hepg2 cells were observed by methyl thiazol tetrazolium (MTT) experiment.ResultsCompared with UV group (0.94±0.13), the expression value of Trim28 in SB203580+ UV group had no significant difference (t=-0.190, P>0.05). Value of phosphorylation-Trim28 in SB203580+ UV group (0.32±0.04) was obviously lower than UV group (0.72±0.05), the difference had statistical meaning (t=8.500, P<0.05); The 24, 48 and 72 hours after UV irradiation, the cell survive rate of UV group [(95±7)%, (62±10)%, (35±6)%] is higher than SB203580+ UV group [(85±7)%, (37±4)%, (20±3)%]. The difference has statistical meaning (t=-2.326, -5.212, -4.577, P<0.05).ConclusionThe viability of HCC cells during DNA damaged can be reduced by inhibition for Trim28 phosphorylation.Key words: Trim28; Phosphorylation; Cell survival" @default.
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- W3031570474 date "2019-12-08" @default.
- W3031570474 modified "2023-09-23" @default.
- W3031570474 title "Effect of trim28 (ser473) phosphorylation on viability of hepatocellular carcinoma cells during DNA damage" @default.
- W3031570474 doi "https://doi.org/10.3760/cma.j.issn.1001-9030.2019.12.018" @default.
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