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- W3031575168 abstract "Crocin is a chemical extraction from saffron and it is the most important kind of pigment of saffron.Recently,the research on cervical cancer,bladder cancer,leukemia,tongue squamous cell carcinoma,colon cancer,pancreatic cancer shows that crocin has a role in inducing apoptosis of the tumor cells by activating caspase-3,regulating the ratio of bcl-2/bax and repressing the expression of survivin.Crocin has a strong inhibitory effect on tumor proliferation by inducing cell cycle to arrest through down-regulating the expression of cyclin D1 and up-regulating the expression of p27kip1.Crocin can also exert antitumor effects by liposome encapsulation to enhance cytotoxic effect.Crocin is a kind of effective chemical for tumor treatment and prevention with no significant toxico-and by-effect in vivo,and is likely to be used as an anticancer drug clinically in the future.Key words: Neoplasms; Cell cycle; Apoptosis" @default.
- W3031575168 created "2020-06-05" @default.
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- W3031575168 date "2012-12-08" @default.
- W3031575168 modified "2023-09-27" @default.
- W3031575168 title "Anticancer effect of crocin" @default.
- W3031575168 doi "https://doi.org/10.3760/cma.j.issn.1673-422x.2012.012.010" @default.
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