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- W3031580514 abstract "Objectives To investigate the expression of fibroblast activation protein (FAP) in the stro-ma of human cervical carcinoma (CC)and its relationship to microvessel density ( MVD). Methods Immuno-histochemical staining was used to detected the expression of FAP and CD34. Results Expression of FAP was observed in 88% (44/50) of fifty cases with CC, while it was negative within normal cervical tissue. The expression of FAP in carcinoma cells was at a low level. The expression of FAP was significantly associated with the clinical stages of CC(χ2 =4. 379 ,P <0.05), but its relation to pathological grades and lymph node metastasis were not significant. The stroma MVD was correlated with clinical stages(χ2 = 13. 116,P <0.01) , but its relation to pathological grades and lymph node metastasis were not significant. The difference of MVD in groups of different FAP intensity was significant(χ2 =44. 199,P<0. 01), and with increasing FAP expression, MVD increased. Conclusion FAP may promote the progression of CC by facilitating tumor angiogenesis.Key words: Cervical carcinoma; FAP; Tumor-associated fibroblasts(TAFs); Angiogenesis" @default.
- W3031580514 created "2020-06-05" @default.
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- W3031580514 date "2010-08-15" @default.
- W3031580514 modified "2023-09-24" @default.
- W3031580514 title "A study of FAP expression and its correlation with MVD in the stroma of cervical carcinoma" @default.
- W3031580514 doi "https://doi.org/10.3760/cma.j.issn.1673-4386.2010.04.006" @default.
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