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- W3031615557 abstract "ObjectiveTo compare the clinical effect of double dose inhaled corticosteroid and inhaled corticosteroid combined with theophylline in the treatment of asthma.MethodsFrom February 2014 to December 2015, 64 asthma patients in our hospital were selected.According to different treatment options, they were divided into control group and observation group.The control group was treated with double dose of inhaled corticosteroid, the observation group was inhaled corticosteroids combined with theophylline.The improvement of clinical symptoms and interleukin-5 (IL-5) changes before and after treatment in two groups were observed and analyzed.ResultsBefore treatment, the clinical symptom scores between the two groups had no statistically significant differences (P>0.05). After six weeks of treatment, the patients' clinical symptom scores[(0.75±0.92)points, (0.62±0.79)points; (0.68±0.84)points, (0.55±0.67)points]were significantly decreased compared with before treatment[(1.53±0.71)points, (1.05±0.83)points; (1.76±0.69)points, (1.08±0.63)min], the differences were statistically significant (t1=-3.797, t2=-5.620, t3=-2.123, t4=-3.260, all P 0.05). After treatment, the sputum supernatant IL-5 levels of the two groups[(43.6±24.7)pg/L, (45.1±23.9)pg/L]were significantly decreased compared with before treatment[(54.5±23.9)pg/L, (55.4±22.8)pg/L](tobservation group=1.794, tcontrol group=1.764, all P 0.05).ConclusionInhaled theophylline combined with hormone therapy in the treatment of asthma can get similar effect as double dose inhaled corticosteroid, and its effect is more safe and reliable, in favor of the primary hospitals.Key words: Asthma; Theophylline; Inhaled corticosteroids; Security" @default.
- W3031615557 created "2020-06-05" @default.
- W3031615557 creator A5042117200 @default.
- W3031615557 date "2016-12-01" @default.
- W3031615557 modified "2023-09-23" @default.
- W3031615557 title "Clinical study of inhaled corticosteroids and theophylline combined with double-dose inhaled corticosteroid therapy for asthma" @default.
- W3031615557 doi "https://doi.org/10.3760/cma.j.issn.1008-6706.2016.23.033" @default.
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