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- W3031623757 abstract "目的寻求适合中国人心脏移植受者FK506理想治疗窗谷浓度范围.方法应用微粒子酶免疫分析法(MEIA)测定6例心脏移植受者口服FK506后全血谷浓度,以FK506谷浓度结合病人临床疗效及不良反应的情况,总结FK506在心脏移植术后的治疗窗.结果术后1年病人的FK506谷浓度控制在5～25 ng/ml,未出现严重的排异反应和肾毒性,但术后早期曾出现头痛和震颤等不良反应.结论 FK506具有良好的免疫抑制效果,其治疗窗谷浓度范围,术后第1个月内为:15～20 ng/ml,第2～3个月10～15 ng/ml,第4～6个月8～12 ng/ml,6个月后5～8 ng/ml,此浓度范围即可有满意的免疫抑制效果,又可减少FK506的肾毒性." @default.
- W3031623757 created "2020-06-05" @default.
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- W3031623757 date "2002-07-25" @default.
- W3031623757 modified "2023-09-25" @default.
- W3031623757 title "Preliminary clinical research of FK506 therapeutic windows trough concentration in Chinese heart transplantation recipients" @default.
- W3031623757 doi "https://doi.org/10.3760/cma.j.issn.1001-4497.2002.04.011" @default.
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