Matches in SemOpenAlex for { <https://semopenalex.org/work/W3031642928> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W3031642928 endingPage "152" @default.
- W3031642928 startingPage "149" @default.
- W3031642928 abstract "Objective To explore the protection of valsartan combined with simvastatin on kidney in early diabetic nephropathy rats. Methods Diabetic nephropathy rats model were induced by streptozocin (STZ) ,the experimental rats were randomly divided into 5 groups: control (group C), diabetic nephropathy (group D) ,diabetes treated with valsartan (group X) ,diabetes treated with simvastatin (group Z) ,and diabetes treated with combined valsartan and simvastatin ( group L). Blood glucose (BG), HbA1c, blood cholesterol ( TC), trigalloylglycerol ( TG ), blood ureanitrogen ( BUN ), serum creatinine (SCr) , urinary albumin excretion rate (UAER) were measured, and the podocyte ultrastructure was observed by transmission electronic microscopy. Results The levels of BG, HbA1c,TC,TG and UAER in group D increased significantly compared togroup C(BG:[20.3 ±3.2]mmol/L vs [6.1 -±0. 4]mmol/L;HbA1c:[7.18 ±0.47]% vs [3.37 ±0. 15]% ;TC: [2. 69 ±0. 35] mmol/L vs [1.28 ±0. 24] mmol/L;TG: [3.09 ±0. 37] mmol/L vs [1.18 ±0. 25]mmol/L) (P ＜ 0. 05 ). Creatinine clearance rates (Ccr) in group D ( [0. 89 ± 0. 19] ml/min ) decreased significantly compared to group C( [1.27 ±0. 33] ml/min) ,as well as group X,Z and L( Ps ＜ 0. 05 ). UAER in group D was significantly higher than that in group C ( [19. 87 ±3. 85] μg/24 h vs [3. 67 ± 1.01] μg/24 h) (P ＜ 0. 05 ), as well as group X, Z and L ( P ＜ 0. 05 ), and the improvement in group L was particularly significant ( P ＜ 0. 05 ). The projections of podocyte in group D severely syncretized, there were slightly improvement in group X, Z and L compared to group D, and the improvement in group L was remarkable. Conclusion The treatment with valsartan, simvastatin and their combination will effectively protect the kidney in early diabetic nephropathy rats,and the effect of using the combination therapy is much better.Key words: Early diabetic nephropathy; Valsartan; Simvastatin; Podocyte" @default.
- W3031642928 created "2020-06-05" @default.
- W3031642928 creator A5013870222 @default.
- W3031642928 creator A5026938141 @default.
- W3031642928 creator A5031165701 @default.
- W3031642928 creator A5033415693 @default.
- W3031642928 creator A5045236201 @default.
- W3031642928 creator A5057410730 @default.
- W3031642928 creator A5057585107 @default.
- W3031642928 creator A5057995628 @default.
- W3031642928 creator A5077322975 @default.
- W3031642928 creator A5086595797 @default.
- W3031642928 date "2011-02-01" @default.
- W3031642928 modified "2023-09-27" @default.
- W3031642928 title "Protection of valsartan combined with simvastatin on the kidney in early diabetic nephropathy rats" @default.
- W3031642928 doi "https://doi.org/10.3760/cma.j.issn.1008-6315.2011.02.012" @default.
- W3031642928 hasPublicationYear "2011" @default.
- W3031642928 type Work @default.
- W3031642928 sameAs 3031642928 @default.
- W3031642928 citedByCount "0" @default.
- W3031642928 crossrefType "journal-article" @default.
- W3031642928 hasAuthorship W3031642928A5013870222 @default.
- W3031642928 hasAuthorship W3031642928A5026938141 @default.
- W3031642928 hasAuthorship W3031642928A5031165701 @default.
- W3031642928 hasAuthorship W3031642928A5033415693 @default.
- W3031642928 hasAuthorship W3031642928A5045236201 @default.
- W3031642928 hasAuthorship W3031642928A5057410730 @default.
- W3031642928 hasAuthorship W3031642928A5057585107 @default.
- W3031642928 hasAuthorship W3031642928A5057995628 @default.
- W3031642928 hasAuthorship W3031642928A5077322975 @default.
- W3031642928 hasAuthorship W3031642928A5086595797 @default.
- W3031642928 hasConcept C10146269 @default.
- W3031642928 hasConcept C126322002 @default.
- W3031642928 hasConcept C126894567 @default.
- W3031642928 hasConcept C134018914 @default.
- W3031642928 hasConcept C159641895 @default.
- W3031642928 hasConcept C2776329913 @default.
- W3031642928 hasConcept C2777387769 @default.
- W3031642928 hasConcept C2779922275 @default.
- W3031642928 hasConcept C2780091579 @default.
- W3031642928 hasConcept C2780306776 @default.
- W3031642928 hasConcept C2781184683 @default.
- W3031642928 hasConcept C555293320 @default.
- W3031642928 hasConcept C71924100 @default.
- W3031642928 hasConcept C84393581 @default.
- W3031642928 hasConceptScore W3031642928C10146269 @default.
- W3031642928 hasConceptScore W3031642928C126322002 @default.
- W3031642928 hasConceptScore W3031642928C126894567 @default.
- W3031642928 hasConceptScore W3031642928C134018914 @default.
- W3031642928 hasConceptScore W3031642928C159641895 @default.
- W3031642928 hasConceptScore W3031642928C2776329913 @default.
- W3031642928 hasConceptScore W3031642928C2777387769 @default.
- W3031642928 hasConceptScore W3031642928C2779922275 @default.
- W3031642928 hasConceptScore W3031642928C2780091579 @default.
- W3031642928 hasConceptScore W3031642928C2780306776 @default.
- W3031642928 hasConceptScore W3031642928C2781184683 @default.
- W3031642928 hasConceptScore W3031642928C555293320 @default.
- W3031642928 hasConceptScore W3031642928C71924100 @default.
- W3031642928 hasConceptScore W3031642928C84393581 @default.
- W3031642928 hasIssue "02" @default.
- W3031642928 hasLocation W30316429281 @default.
- W3031642928 hasOpenAccess W3031642928 @default.
- W3031642928 hasPrimaryLocation W30316429281 @default.
- W3031642928 hasRelatedWork W212070899 @default.
- W3031642928 hasRelatedWork W2349054606 @default.
- W3031642928 hasRelatedWork W2351242056 @default.
- W3031642928 hasRelatedWork W2353249675 @default.
- W3031642928 hasRelatedWork W2356406058 @default.
- W3031642928 hasRelatedWork W2364275555 @default.
- W3031642928 hasRelatedWork W2368783752 @default.
- W3031642928 hasRelatedWork W2368852909 @default.
- W3031642928 hasRelatedWork W2371973832 @default.
- W3031642928 hasRelatedWork W2373431057 @default.
- W3031642928 hasRelatedWork W2377176183 @default.
- W3031642928 hasRelatedWork W2378923607 @default.
- W3031642928 hasRelatedWork W2380170181 @default.
- W3031642928 hasRelatedWork W2380684756 @default.
- W3031642928 hasRelatedWork W2381701256 @default.
- W3031642928 hasRelatedWork W3028617076 @default.
- W3031642928 hasRelatedWork W3030412973 @default.
- W3031642928 hasRelatedWork W3030768707 @default.
- W3031642928 hasRelatedWork W3031758882 @default.
- W3031642928 hasRelatedWork W3147551600 @default.
- W3031642928 hasVolume "27" @default.
- W3031642928 isParatext "false" @default.
- W3031642928 isRetracted "false" @default.
- W3031642928 magId "3031642928" @default.
- W3031642928 workType "article" @default.