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- W3031644432 abstract "Objective To explore diaphragmatic function and the influence of controlled mechanical ventilation on diaphragmatic function in chronic obstructive pulmonary disease(COPD) model rats. Methods Dripping lipopolysaccharide applied to trachea and passive smoking were applied to replicate the model of COPD; the changes of trans-diaphragmatic pressure and spectrum analysis of electromyogram of diaphragmatic muscle in normal rats and COPD rats were compared; the effect of short term controlled mechanical ventilation on diaphragmatic function of COPD rats was observed. Results FEVo.s/FVC decreased in rats in model group compared with that in normal group (88. 05±5.87)% vs (69.41± 11.50)% (P <0.05). The transdiaphragmatic pressure of model group was lower than that of control group (4. 28±1.03) cm H2O vs (5.36±0.94) cm H2O (P <0.05). Results of spectral analysis of electromyographic signal of diaphragmatic muscle in ratio by high frequency and low frequency were lower in model group than those in control group (P < 0.05). However, it was increased significantly in low frequency in model group. Results of trans-diaphragmatic pressure and spectrum analysis of etectromyographic signal of diaphragmatic muscle before and after mechanical ventilation in rats of COPD model were of no significant difference ( P < 0.05). Conclusions By trans-diaphragmatic pressure and spectrum analysis of electromyographic signal of diaphragmatic muscle measuring, it is indicated that diaphragmatic function decreases in rats with COPD. Short term (6 hours ) controlled mechanical ventilation has no significant effect on diaphragmatic function in rats with COPD.Key words: Chronic obstructive pulmonary disease; Diaphragmatic function; Lipopolysaccharide Controlled mechanical ventilation; Passive smoking" @default.
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- W3031644432 date "2009-08-05" @default.
- W3031644432 modified "2023-09-27" @default.
- W3031644432 title "Experimental study on diaphragmatic function in rats with chronic obstructive pulmonary disease" @default.
- W3031644432 doi "https://doi.org/10.3760/cma.j.issn.1673-436x.2009.015.003" @default.
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