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- W3031649515 abstract "目的 观察胸苷激酶/丙氧鸟苷(TK/GCV)、胞嘧啶脱氨酶/5-氟胞嘧啶(CD/5-Fc)双自杀基因系统对结肠癌的治疗效果,并结合研究结果进行作用机理的分析.方法 采用培养细胞移植法,将人结肠癌细胞系SW480接种于裸鼠背部皮下,建立裸鼠人结肠癌移植瘤模型.将32只裸鼠随机分为4组:空白对照组,TK/GCV治疗组,CD/5-Fc治疗组,TK/GCV+CD/5-Fc联合治疗组,每组8只.TK/GCV+CD/5-Fc采用逆转录病毒介导,采用瘤体内直接注射法,同时腹腔注射GCV、5-Fc治疗,观察各组小鼠的生存状况及肿瘤体积、瘤重、肿瘤生长抑制率、常规病理、生存期等指标,比较观察各治疗组的治疗效果及对荷瘤裸鼠存活的影响.结果 各治疗组裸鼠人结肠癌移植瘤的生长均受到显著抑制,治疗后各组体积数增加(P＜0.05),治疗组裸鼠存活期显著延长,TK/GCV+CD/5-Fc联合治疗组效果最好,疗效q值=1.675＞1.15,即TK/GCV、CD/5-Fc有交互协同作用.结论 TK/GCV与CD/5-Fc对人结肠癌SW480细胞有明显抑制作用,TK/GCV、CD/5-Fc双自杀基因系统效果更强。" @default.
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- W3031649515 date "2006-11-20" @default.
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- W3031649515 title "Treatment of human colocarcinoma with gene therapy system of TK/GCV and CD/5-Fc in nude mice" @default.
- W3031649515 doi "https://doi.org/10.3760/cma.j.issn.1673-9752.2006.06.020" @default.
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