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- W3031662007 abstract "目的 探讨首发精神分裂症患者氯氮平治疗前后血浆白细胞介素6(IL-6)、白细胞介素13(IL-13)及可溶性白细胞介素6受体(sIL-6R)水平的变化.方法采用双抗体夹心ABC-放射免疫吸附法,对30例(男10 例,女20 例)首发精神分裂症患者(患者组)氯氮平治疗前后及28名(男13名,女15名)健康对照者(对照组)的血浆IL-6、IL-13及sIL-6R水平进行检测.结果 (1)患者组治疗前[(20.2±2.6)ng/L]后[(21.7±2.8)ng/L]血浆IL-6水平均明显高于对照组[(18.1±3.6)ng/L],差异均有统计学意义(均P<0.05).患者组氯氮平治疗后血浆IL-6水平高于治疗前(P<0.05).(2)患者组治疗第6周末血浆sIL-6R水平[(23±20)ng/L]比治疗前[(34±16)ng/L]明显下降,差异有统计学意义(P<0.05).(3)患者组治疗前血浆IL-13水平[(16±12) ng/L]明显低于对照组 [(24±18) ng/L],差异有统计学意义(P<0.05),治疗第6周末[(22±14) ng/L]比治疗前有所升高.(4)经相关及多元回归分析,患者组治疗第6周末血浆IL-6水平的增高幅度与氯氮平治疗剂量呈正相关,差异有统计学意义(r=0.722,P=0.000);治疗前血浆sIL-6R水平与阳性症状分呈正相关(r=0.379,P=0.020),血浆IL-13水平与阴性症状分(r=-0.602,P=0.000)及阳性和阴性症状量表总分(r=-0.334,P=0.035)呈负相关;治疗前后IL-13的变化幅度与阴性症状分减分率呈正相关(r=0.611,P=0.000).结论首发精神分裂症患者的IL-6、sIL-6R、 IL-13存在异常。" @default.
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- W3031662007 date "2005-02-05" @default.
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- W3031662007 title "The changes of plasma IL-6,sIL-6R and IL-13 in patients with first-episode schizophrenia before and after clozapine treatment" @default.
- W3031662007 doi "https://doi.org/10.3760/j:issn:1006-7884.2005.01.004" @default.
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