Matches in SemOpenAlex for { <https://semopenalex.org/work/W3031674443> ?p ?o ?g. }
Showing items 1 to 80 of
80
with 100 items per page.
- W3031674443 endingPage "657" @default.
- W3031674443 startingPage "653" @default.
- W3031674443 abstract "ObjectiveTo investigate the clinical value of blood coagulation and fibrinolysis index detection in lymphoma patients.MethodsA total of 115 lymphoma patients hospitalized at Zhongshan Hospital of Xiamen University from January 2013 to September 2017 were retrospectively analyzed. According to the diagnostic and therapeutic criteria of lymphoma from World Health Organization (2008), these patients were divided into chemotherapy remission group (76 cases) and chemotherapy non-remission group (39 cases). A total of 138 healthy examination subjects at the same period were selected as the control group. Coagulation factor Ⅶ (FⅦ), D-dimer (D-D), von Willebrand factor antigen (vWF: Ag) and serum lactate dehydrogenase (LDH) levels were measured in all subjects. Kruskal-Wallis test was used to compare the differences of blood coagulation and fibrinolysis indicators in patients with different lymphoma staging and stratified treatment outcomes. Correlation test of D-D and LDH and disease staging was performed by using Spearman correlation analysis. The receiver operating characteristics (ROC) curve was used to analyze the efficacy of D-D in the assisted diagnosis of lymphoma with thrombosis.ResultsThe plasma D-D, vWF: Ag levels and FⅦ activity [the median (interquartile range)] in lymphoma patients were higher than those in healthy controls [1 240 ng/ml (1 610 ng/ml) vs. 250 ng/ml (43 ng/ml), Z = -10.728, P < 0.01; 170 ng/ml (113 ng/ml) vs. 105 ng/ml (28 ng/ml), Z = -6.425, P < 0.01; 120% (26%) vs. 96% (26%), Z = -4.602, P < 0.01]. With the increase of Ann Arbor stage, plasma D-D, vWF: Ag levels and FⅦ activity were also increased gradually (all P < 0.05); plasma D-D, vWF: Ag levels and FⅦ activity in lymphoma with thrombosis group were higher than those in the group without thrombosis (all P < 0.01), D-D and vWF: Ag levels in the chemotherapy remission group were lower than those in the chemotherapy non-remission group (all P < 0.01). Plasma D-D levels were positively correlated with LDH level and Ann Arbor stage (r values were 0.414 and 0.530, respectively, all P < 0.01). When the plasma D-D level was 1 735 ng/ml, the sensitivity of diagnosis of thrombosis in patients with lymphoma was 81.8%, the specificity was 85.7%, the area under the ROC curve was 0.894, and the Youden index was the highest (0.675).ConclusionsClinically, blood coagulation and fibrinolysis in patients with lymphoma can be evaluated by detecting blood coagulation and fibrinolysis indexes such as plasma D-D. Real-time monitoring of plasma D-D level can determine the thrombosis trend of lymphoma patients, and it may play an important role in evaluating the efficacy and prognosis.Key words: Lymphoma; D-dimer; von Willebrand factor antigen; Blood coagulation factor Ⅶ" @default.
- W3031674443 created "2020-06-05" @default.
- W3031674443 creator A5000660688 @default.
- W3031674443 creator A5016320809 @default.
- W3031674443 creator A5074626626 @default.
- W3031674443 creator A5083832879 @default.
- W3031674443 date "2019-11-25" @default.
- W3031674443 modified "2023-09-24" @default.
- W3031674443 title "Expressions of plasma D-dimer, von Willebrand factor antigen and blood coagulation factor VII in lymphoma and their clinical significances" @default.
- W3031674443 doi "https://doi.org/10.3760/cma.j.issn.1009-9921.2019.11.003" @default.
- W3031674443 hasPublicationYear "2019" @default.
- W3031674443 type Work @default.
- W3031674443 sameAs 3031674443 @default.
- W3031674443 citedByCount "0" @default.
- W3031674443 crossrefType "journal-article" @default.
- W3031674443 hasAuthorship W3031674443A5000660688 @default.
- W3031674443 hasAuthorship W3031674443A5016320809 @default.
- W3031674443 hasAuthorship W3031674443A5074626626 @default.
- W3031674443 hasAuthorship W3031674443A5083832879 @default.
- W3031674443 hasConcept C119060515 @default.
- W3031674443 hasConcept C126322002 @default.
- W3031674443 hasConcept C181199279 @default.
- W3031674443 hasConcept C185592680 @default.
- W3031674443 hasConcept C2776825266 @default.
- W3031674443 hasConcept C2777318727 @default.
- W3031674443 hasConcept C2778382381 @default.
- W3031674443 hasConcept C2778476033 @default.
- W3031674443 hasConcept C2779338263 @default.
- W3031674443 hasConcept C2779394231 @default.
- W3031674443 hasConcept C2780653079 @default.
- W3031674443 hasConcept C55493867 @default.
- W3031674443 hasConcept C71924100 @default.
- W3031674443 hasConcept C89560881 @default.
- W3031674443 hasConcept C90924648 @default.
- W3031674443 hasConceptScore W3031674443C119060515 @default.
- W3031674443 hasConceptScore W3031674443C126322002 @default.
- W3031674443 hasConceptScore W3031674443C181199279 @default.
- W3031674443 hasConceptScore W3031674443C185592680 @default.
- W3031674443 hasConceptScore W3031674443C2776825266 @default.
- W3031674443 hasConceptScore W3031674443C2777318727 @default.
- W3031674443 hasConceptScore W3031674443C2778382381 @default.
- W3031674443 hasConceptScore W3031674443C2778476033 @default.
- W3031674443 hasConceptScore W3031674443C2779338263 @default.
- W3031674443 hasConceptScore W3031674443C2779394231 @default.
- W3031674443 hasConceptScore W3031674443C2780653079 @default.
- W3031674443 hasConceptScore W3031674443C55493867 @default.
- W3031674443 hasConceptScore W3031674443C71924100 @default.
- W3031674443 hasConceptScore W3031674443C89560881 @default.
- W3031674443 hasConceptScore W3031674443C90924648 @default.
- W3031674443 hasIssue "11" @default.
- W3031674443 hasLocation W30316744431 @default.
- W3031674443 hasOpenAccess W3031674443 @default.
- W3031674443 hasPrimaryLocation W30316744431 @default.
- W3031674443 hasRelatedWork W2013758721 @default.
- W3031674443 hasRelatedWork W2014999618 @default.
- W3031674443 hasRelatedWork W2326494122 @default.
- W3031674443 hasRelatedWork W2341539741 @default.
- W3031674443 hasRelatedWork W2349355961 @default.
- W3031674443 hasRelatedWork W2350671922 @default.
- W3031674443 hasRelatedWork W2366392708 @default.
- W3031674443 hasRelatedWork W2387631080 @default.
- W3031674443 hasRelatedWork W2410860253 @default.
- W3031674443 hasRelatedWork W2416593449 @default.
- W3031674443 hasRelatedWork W2419406559 @default.
- W3031674443 hasRelatedWork W2558862514 @default.
- W3031674443 hasRelatedWork W3025782680 @default.
- W3031674443 hasRelatedWork W3029937751 @default.
- W3031674443 hasRelatedWork W3030657418 @default.
- W3031674443 hasRelatedWork W3030875284 @default.
- W3031674443 hasRelatedWork W3030897320 @default.
- W3031674443 hasRelatedWork W3031543433 @default.
- W3031674443 hasRelatedWork W3146206248 @default.
- W3031674443 hasRelatedWork W3029864492 @default.
- W3031674443 hasVolume "28" @default.
- W3031674443 isParatext "false" @default.
- W3031674443 isRetracted "false" @default.
- W3031674443 magId "3031674443" @default.
- W3031674443 workType "article" @default.