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- W3031684771 abstract "目的 探讨PSTAT3和VEGF蛋白在胰腺癌组织中的表达情况及其与胰腺癌临床病理特征、胰腺癌组织中血管新生的关系.方法用免疫组织化学检测了41例手术切除的胰腺癌组织和10例正常胰腺组织中PSTAT3、VEGF的蛋白表达和微血管密度.结果在41例胰腺癌标本中有29(70.7%)例PSTAT3和31(75.6%)例VEGF蛋白的表达阳性,明显高于正常胰腺组织.PSTAT3和VEGF蛋白的阳性表达呈正相关(r=0.758,P＜0.01).PSTAT3在临床分期较晚和有淋巴结转移的胰腺癌中呈高表达(P=0.003,0.033),VEGF的表达与临床分期有关(P=0.025).41例胰腺癌组织中的微血管密度MVD与PSTAT3、VEGF蛋白的阳性表达有关(P=0.003,0.001).结论胰腺癌组织中存在PSTAT3和VEGF的过表达,PSTAT3与临床病理分期和淋巴结转移有关,PSTAT3可能通过上调VEGF的表达,促进胰腺癌组织中新生血管的形成,可能在胰腺癌的发生发展中起到重要作用。" @default.
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- W3031684771 date "2006-07-28" @default.
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- W3031684771 title "Expression of PSTAT3 and VEGF in pancreatic carcinoma and its clinical significance" @default.
- W3031684771 doi "https://doi.org/10.3760/cma.j.issn.1007-8118.2006.07.012" @default.
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