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- W3031685655 abstract "ObjectiveTo evaluate the safety of total proctocolectomy (TPC) + ileal pouch anal anastomosis (IPAA) and postoperative pouch and sexual function in ulcerative colitis (UC) patients.MethodsClinical data of UC patients undergoing TPC+IPAA from March 2011 to January 2018 in our hospital were retrospectively collected. Postoperative follow-up ended in June 2018. Patients were divided into subgroups according to whether developing postoperative complications, pouch function disorder (incontinence or defecation >8 times/d) and sexual function disorder (disorder of erection, sexual evocation or ejaculation) . Chi-square test and logistic regression were used to analyze the risk factors for postoperative complications, pouch function and sexual function.ResultsA total of 43 UC patients receiving TPC+IPAA were enrolled and 45 cases of postoperative complications were found in 21 patients including pouchitis (16 cases, 35.6%) , anastomotic stricture (7 cases, 15.6%) and anastomotic leakage (6 cases, 13.3%) without severe complication. The proportion of 3-stage IPAA in patients without complication was significantly higher as compared to those with complication (59.1% vs. 23.8%, P = 0.019) , and 3-stage IPAA procedure decreased complication in UC surgery (OR = 0.216, 95% CI: 0.058-0.806, P<0.05) . Twenty-four patients completed stoma closure and their defecation and sexual function were evaluated after (33.29±22.37) months, of whom 9 cases (37.5%) developed pouch dysfunction and 8 cases (33.3%) developed sexual dysfunction. No significant differences of preoperative glucocorticoid treatment, infliximab treatment, surgical method, surgical timing and IPAA stage were found between with and without pouch dysfunction groups, with and without sexual dysfunction groups.ConclusionsTPC+IPAA is feasible and effective in treating UC patients. Most UC patients can maintain normal defecation function and sexual function after surgery. Three-stage IPAA is a protective factor for postoperative complication of TPC+IPAA.Key words: Inflammatory bowel disease; Ulcerative colitis; Ileal pouch anal anastomosis; Total proctocolectomy" @default.
- W3031685655 created "2020-06-05" @default.
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- W3031685655 date "2019-10-25" @default.
- W3031685655 modified "2023-09-26" @default.
- W3031685655 title "Safety and functional evaluation of total proctocolectomy plus ileal pouch anal anastomosis for ulcerative colitis" @default.
- W3031685655 doi "https://doi.org/10.3760/cma.j.issn.2096-367x.2019.04.011" @default.
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